Results 141 to 150 of about 144,720 (218)

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Savour the flavour, save the planet: climate sensitivity information on menus. [PDF]

Public Health Nutr
Pacaol NF.
europepmc   +1 more source

An Assessment of Earth's Climate Sensitivity Using Multiple Lines of Evidence. [PDF]

Rev Geophys, 2020
Sherwood SC, Webb MJ, Annan JD, Armour KC, Forster PM, Forster PM, Hargreaves JC, Hegerl G, Klein SA, Marvel KD, Rohling EJ, Watanabe M, Andrews T, Braconnot P, Bretherton CS, Foster GL, Hausfather Z, von der Heydt AS, Knutti R, Mauritsen T, Norris JR, Proistosescu C, Rugenstein M, Schmidt GA, Tokarska KB, Zelinka MD.   +25 more
europepmc   +1 more source

Single‐Cell Transcriptomics and Metabolomics Reveal Glutamate Dehydrogenase as a Central Regulator of Nitrogen Metabolic Remodeling During Alkalinity Adaptation in Crustaceans

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals the cellular response of Macrobrachium hainanense to carbonate alkalinity stress. Alkalinity stress impairs branchial ammonia excretion, induces mitochondrial dysfunction, and drives cell‐type‐specific changes in gills and hemocytes.
Yiting Jin, Zhimin Lv, Chao Bian, Qibin Yang, Na Zhou, Jianguang Qin, Shengming Sun   +6 more
wiley   +1 more source

Beyond maximum density: multi-parameter insights into Scots pine climate sensitivity. [PDF]

Trees (Berl West)
Homfeld IK, Reinig F, Del Castillo EM, Torbenson MCA, Konter O, Wilson R, Wilson R, Krusic PJ, Loader NJ, Grudd H, Reid E, Letherbarrow K, Esper J.   +12 more
europepmc   +1 more source

Proxy evidence for state-dependence of climate sensitivity in the Eocene greenhouse. [PDF]

Nat Commun, 2020
Anagnostou E, John EH, Babila TL, Sexton PF, Ridgwell A, Lunt DJ, Pearson PN, Chalk TB, Pancost RD, Foster GL.   +9 more
europepmc   +1 more source

Intranasal Delivery of Gallium–Quercetin Nanoparticles for Multi‐Target Ferroptosis Inhibition in Parkinson's Disease

Advanced Science, EarlyView.
Leveraging the chemical similarity between Ga3+ and Fe3+ as well as the antioxidant properties of quercetin, gallium–quercetin nanoparticles (GQNPs) were prepared to integrate iron homeostasis regulation, oxidative stress suppression, and mitochondrial protection for multi‐target ferroptosis inhibition in Parkinson's Disease.
Keyang Xu, Dandan Kou, Xiao Xiao, Bingbing Bai, Caide Liu, Mengyao Wu, Yadan Shi, Mengdan Xu, Xiaoyi Cao, Haodi Qi, Shuhua Wu, Jianfeng Zeng, Mingyuan Gao   +12 more
wiley   +1 more source

Photothermal drivers and climate-sensitivity windows of Lanzhou lily (<i>Lilium davidii</i> var. <i>unicolor</i>) phenology across three decades of warming in Northwest China. [PDF]

Front Plant Sci
Ma X, Yue R, Li H, Liu X, Pei Y, Zhao R, Wu Y, Jin L.   +7 more
europepmc   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

No apparent state-dependency of equilibrium climate sensitivity between the Pleistocene glacial and interglacial climate states. [PDF]

Nat Commun
Da J, Zhang YG, Liu X, Breecker DO, Li GK, Chen T, Ji J.   +6 more
europepmc   +1 more source