Results 301 to 310 of about 28,341,257 (369)

A System of Systems for the Selection of Optimal Climate Change Decisions

G. Piccoli, Lucia Sangiorgi, Claudio Carnevale, S. De Nardi, Sara Raccagni   +4 more
openalex   +1 more source

Gut Microbiota‐Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol‐Induced Cognitive and Social Dysfunction via CB1R‐DRD2‐RAP1 Signaling Axis

Advanced Science, EarlyView.
This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang, Zibin Li, Yao Xiao, Ji Bian, Caian He, Chao Liu, Lan Gong, Lin Han, Zhigang Liu, Min Wang   +9 more
wiley   +1 more source

Assessing rice yield responses to climate change scenarios using a crop simulation model. [PDF]

PeerJ
Baydar A.
europepmc   +1 more source

Effects of climate change on the Flemish water system (Belgium) [PDF]

, 2009
De Sutter, Renaat, Ingle, Ruchita
core   +1 more source

Remimazolam Ameliorates Autistic‐Like Behaviors via Suppression of Ferroptosis in VTA Dopaminergic Neurons in a Mouse Model of ASD

Advanced Science, EarlyView.
The ultra‐short‐acting sedative remimazolam has a sustained therapeutic effect on the core symptoms of VPA‐exposed mice. Remimazolam, a GABA agonist, exerts its therapeutic effects by protecting dopamine neurons in the VTA of VPA‐exposed mice. Meanwhile, ferroptosis is the critical mechanism by which remimazolam protects VTA dopaminergic neurons and ...
Yuxin Zhang, Jianwei Lin, Chaoyang Tong, Xin Fu, Mengqin Shan, Yue Huang, Kan Zhang, Jijian Zheng   +7 more
wiley   +1 more source

Values, trade-offs and ethical choices in climate-related health research. [PDF]

Bull World Health Organ
Singh JA.
europepmc   +1 more source

Generalized Mechanism Model for Ecosystem Hysteresis

Advanced Science, EarlyView.
A simplified model examines ecosystem transitions into alternative states after disturbances by leveraging positive and negative feedbacks. It identifies critical tipping points and quantifies hysteresis. Tests conducted on lakes, grasslands, and pitcher‐plant leaves align closely with empirical data and enable the prediction of recovery trajectories ...
Yanbin Hao, Xin Wang, Jie Liu, Mingzi Wu, Jianqing Du, Kai Xue, Xiaoning Song, Xiaoyong Cui, Tong Zhao, Yanfen Wang   +9 more
wiley   +1 more source

How AI Shapes the Future Landscape of Sustainable Building Design With Climate Change Challenges? [PDF]

Adv Sci (Weinh)
Shen P, Gao X, Lu S, Zhang Y, Zheng X, Santamouris M.   +5 more
europepmc   +1 more source

The climate system

, 2016
Arto, I., Capellán-Pérez, I., Filatova, T., Gonzá-lez-Eguinob, M., Hasselmann, K., Kovalevsky, D., Markandya, A., Moghayer, S., Tariku, M.   +8 more
openaire   +1 more source

A Novel Function of Nonadecanoic Acid in Regulating Glucose Homeostasis

Advanced Science, EarlyView.
This study identifies the odd‐chain fatty acid C19:0 as an endogenous ligand of GPR120 that promotes glucose homeostasis via Gαq signaling. In obesity, elevated palmitic acid suppresses endogenous C19:0 production through a miRNA–PPARα–HACL1 pathway, offering a promising direction for understanding the role of OCFAs in human health.
Yanting Hou, Yinghua Ma, Qin Liu, Dingling Ma, Yuxin Tong, Lili Xu, Xiaolong Chu, Jingzhou Wang, Maodi Liang, Mengyuan Zhao, Huizi Zhang, Yurui Su, Jianxin Xie, Cuizhe Wang, Jun Zhang   +14 more
wiley   +1 more source