Results 61 to 70 of about 28,341,257 (369)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Science Advances, 2020 A historical context is provided for interpreting the equilibrium climate sensitivity (ECS) and transient climate response (TCR). For the current generation of earth system models participating in the Coupled Model Intercomparison Project Phase 6 (CMIP6),
G. Meehl +7 more
semanticscholar +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Impact of potential climate change on plant available soil water and percolation in the Upper Danube basin [PDF]
, 2010 The soil root zone of the land surface provides plants with water for transpiration and therefore biomass production and its excess water percolates downwards and ultimately recharges the groundwater aquifers.
Heinzeller, Christoph +2 more
core +1 more source
The aerosol-monsoon climate system of Asia: A new paradigm
Journal of Meteorological Research, 2016 This commentary is based on a series of recent lectures on aerosol-monsoon interactions I gave at the Beijing Normal University in August 2015. A main theme of the lectures is on a new paradigm of “An Aerosol-Monsoon-Climate-System”, which posits that ...
W. Lau
semanticscholar +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
The global warming potential of near-surface emitted water vapour
Environmental Research Letters, 2018 Water vapour is the most abundant and powerful greenhouse gas in Earth’s atmosphere, and is emitted by human activities. Yet the global warming potential (GWP) and radiative forcing (RF) of emitted water vapour have not been formally quantified in the ...
Steven C Sherwood +2 more
doaj +1 more source
Fracture-induced softening for large-scale ice dynamics [PDF]
The Cryosphere, 2014 Floating ice shelves can exert a retentive and hence stabilizing force onto the inland ice sheet of Antarctica. However, this effect has been observed to diminish by the dynamic effects of fracture processes within the protective ice shelves, leading to ...
T. Albrecht, A. Levermann
doaj +1 more source
The CO2 mitigation and Exergo- and Environ- economics analysis of Bio-gas integrated Semi-transparent Photo-voltaic Thermal (Bi-iSPVT) system for Indian composite climate [PDF]
, 2022 G.N. Tiwari +3 more
openalex +1 more source
Analysis of Climate Policy Targets under Uncertainty [PDF]
, 2009 and PDF report are also available on the MIT Joint Program on the Science and Policy of Global Change website (http://globalchange.mit.edu/).Although policymaking in response to the climate change is essentially a challenge of risk management, most ...
Forest, Chris Eliot +11 more
core +1 more source