Results 31 to 40 of about 2,906,823 (288)

Climate change and climate variability

, 2021
Climate extremes, as recurring events, are the result of natural climate variability (including phenomena such as El Niño), which can have significant local and regional impacts on the society and the environment. These events are typically related to unusually high or low temperature, prolonged dry or wet conditions, heavy precipitation, or extreme ...
Alves, Lincoln Muniz, Fowler, Hayley, Barreto, Naurinete de Jesus da Costa, Llopart, Marta   +3 more
openaire   +2 more sources

Climate trends and variability at adaptation scale: Patterns and perceptions in an agricultural region of the Ethiopian Highlands

Weather and Climate Extremes, 2020
Analysis of climate variability and trends frequently takes place at large scale. For agricultural applications, however, highly localized climate conditions can be critically important.
Dereje Ademe, Benjamin F. Ziatchik, Kindie Tesfaye, Belay Simane, Getachew Alemayehu, Enyew Adgo   +5 more
doaj   +1 more source

Clinical Course and Impact of Breaks in Therapy for Children With Relapsed/Refractory Solid Tumors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Pediatric relapsed or refractory (R/R) solid tumors carry a dismal prognosis, and postrelapse patient experiences are not well described. We present postrelapse outcomes, including number of R/R events and subsequent therapy regimens.
Matthew T. McEvoy, Elizabeth L. Seashore, W. Susan Cheng, Shondra Clay, Jessica A. Casas, Jennifer H. Foster   +5 more
wiley   +1 more source

Near future projections of tropical cyclone tracks over the Bay of Bengal using high resolution CMIP6 models

Scientific Reports
Future changes in tropical cyclone (TC) characteristics play a critical role in shaping the impacts and risks associated with climate change. In this study, we analyzed the near-future projections (2015–2050) by the high-resolution CMIP6-HighResMIP ...
Rushikesh Adsul, Vineet Kumar Singh, Anant Parekh, C. Gnanaseelan   +3 more
doaj   +1 more source

Prevalence of Self-Medicated Use of Antibiotics among the Population in Ernakulam District in Kerala, India

Medical Sciences Forum
Self-medication (SM) of antibiotics has become a prevalent reason for the development of antibiotic resistance. This study aims to assess the use of self-medication practices with antibiotics and related factors among the population of Ernakulam district,
Divya Nair, Padinchare Veettil Gayathri, Girish Gopinath   +2 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

More extreme summertime North Atlantic Oscillation under climate change

Communications Earth & Environment
Extreme states of the North Atlantic Oscillation in summer can lead to severe weather events such as heatwaves and floods in Europe. But how these extremes evolve in response to climate change remains unexplored.
Quan Liu, Jürgen Bader, Johann H. Jungclaus, Daniela Matei   +3 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Hydrogeochemical processes and physicochemical parameters controlling the groundwater chemistry of a tropical river basin, Southern India

Discover Geoscience
The hydrogeochemical characteristics of groundwater in the Achankovil River Basin (ARB), Southern Kerala, India, were investigated to elucidate the dominant geochemical processes influencing water quality. A total of 75 groundwater samples were collected
N. Anjali, A. R. Sabitha, A. L. Achu, C. D. Aju, Girish Gopinath   +4 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source