Results 141 to 150 of about 840,709 (301)

mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

Advanced Science, EarlyView.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim, Huajie Wang, Gao Qianqian, Abdul Waris, Jufang He   +4 more
wiley   +1 more source

Mechanisms of generation and accumulation of geogenic Cr(VI) in serpentinite-weathered soils

Geoderma
Natural oxidation of geogenic Cr(III) to carcinogenic Cr(VI) is a major source of Cr contamination in soil and water. However, the mechanisms of Cr(VI) generation and occurrence under anoxic conditions remain unclear.
Rouyun Zhou, Bolang Luo, Ming Ao, Taicong Liu, Ruichun Meng, Loua-Augustin Bonaventure, Xiaoli Qian, Jean-Louis Morel, Pan Wu, Shizhong Wang, Rongliang Qiu   +10 more
doaj   +1 more source

Exploring seasonal diurnal surface temperature variation in cities based on ECOSTRESS data: A local climate zone perspective. [PDF]

Front Public Health, 2022
Shi Z, Yang J, Wang LE, Lv F, Wang G, Xiao X, Xia J.   +6 more
europepmc   +1 more source

Depletion of p75NTR in Schwann Cells Driven by Inflammation Mediates Cutaneous Pain in Psoriasis

Advanced Science, EarlyView.
Psoriasis‐like inflammation induces proliferation and molecular remodeling of cutaneous Schwann cells, marked by reduced p75NTR and increased NGF expression. IL‐17A promotes this process, whereas Schwann cell‐specific p75NTR overexpression alleviates cutaneous pain in vivo.
Yibo Wang, Linlin Xu, Chenglong Pan, Ruonan Cao, Piao Zeng, Xinxing Lyu, Qingxia Hu, Zhenzhen Yan, Shuhong Huang, Ningning Dang   +9 more
wiley   +1 more source

Zone Matcher: A climate‐based web application for deployment and assisted migration of forest trees

Ecosphere
Populations of forest trees are generally adapted to the climates they inhabit. The farther trees are moved from their local climates, the more long‐term growth and survival tend to decrease.
Tal J. Shalev, Meridith L. McClure, Nikolas Stevenson‐Molnar, Gregory A. O'Neill, Tongli Wang, Joseph A. E. Stewart, Glenn T. Howe   +6 more
doaj   +1 more source

Seasonal SUHI Analysis Using Local Climate Zone Classification: A Case Study of Wuhan, China. [PDF]

Int J Environ Res Public Health, 2021
Shi L, Ling F, Foody GM, Yang Z, Liu X, Du Y.   +5 more
europepmc   +1 more source

Gasdermin D‐Mediated Release of IL‐33 Results in Fetal Brain Developmental Abnormalities During Maternal Colitis

Advanced Science, EarlyView.
Under colitis, Gsdmd mediates the release of IL‐33 from the epithelium of pregnant mice. IL‐33 can cross the placenta and enhance the proliferative capacity of neural stem cells, ultimately resulting in behavioral deficits in the offspring. Excessive pyroptosis in the colonic epithelium also triggers the translocation of LPS, which in turn increases ...
Huiyang Jia, Shukui Zhang, Kai Ma, Jie Zhou, Jianwei Jiao   +4 more
wiley   +1 more source

Interpretable machine learning analysis of environmental characteristics on bacillary dysentery in Sichuan Province

Frontiers in Public Health
BackgroundBacterial dysentery (BD) is a leading cause of diarrhea-related mortality globally, with its incidence heavily influenced by environmental factors.
Yao Zhang, Qiao-Lin Wang, Wei Peng, Meng-Yuan Zhang, Yao Qin, Lun Zhang, Rong-Jie Wei, Dian-Ju Kang   +7 more
doaj   +1 more source

The White Stone Band of the Kimmeridge Clay Formation, an integrated high resolution approach to understanding environmental change

, 2004
The Kimmeridge Clay is a Jurassic mudrock succession that shows Milankovitch Band climatic cyclicity. A key issue is to determine how the subtle changes that define this cyclicity result from climatic change.
Kemp, A.E.S., Marshall, J.E.A., Pearson, S.J.   +2 more
core  

Multi‐Omics Insights Into the Mechanisms of Early Muscle Fiber Difference and Transformation Between Lean‐Type and Chinese Indigenous Pigs

Advanced Science, EarlyView.
Multi‐omics analyses uncover breed‐specific cis‐regulatory landscapes and higher‐order chromatin architectural differences that underlie early postnatal muscle fiber divergence in pigs. A super‐enhancer upstream of PPP3CB recruits MEF2C to activate PPP3CB transcription, while the PPP3CB–MEF2C positive feedback loop promotes oxidative muscle fiber ...
Shuailong Zheng, Hainan Wu, Min Liu, Kunpeng Wu, Shuntao Huang, Zulfiqar Ahmed, Lenox Pius, Mengjin Zhu, Dequan Xu   +8 more
wiley   +1 more source