Results 111 to 120 of about 612,341 (304)

A multidisciplinary coastal vulnerability assessment for local government focused on ecosystems, Santa Barbara area, California [PDF]

, 2019
Incorporating coastal ecosystems in climate adaptation planning is needed to maintain the well-being of both natural and human systems. Our vulnerability study uses a multidisciplinary approach to evaluate climate change vulnerability of an urbanized ...
Myers, Monique
core  

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Comparison of shallow basement thermal performance for different regions of Morocco using a three-dimensional heat transfer analysis

Cogent Engineering, 2019
A three-dimensional numerical model was built to estimate the heat transfer between the soil and a shallow basement in four different climates (cold, temperate, semi-arid and arid climates) for, respectively, conditioned and unconditioned cases.
Naima Sakami, Lahcen Boukhattem, Hassan Hamdi, Brahim Benhamou   +3 more
doaj   +1 more source

Dissecting the Ecological Structure of Health and Disease in the Global Gut Microbiome

Advanced Science, EarlyView.
We introduce Wiredancer, a framework that identifies three continuous ecological factors of the gut microbiota. These factors exhibit distinct patterns across health and disease, jointly capturing disrupted ecological stability and offering a new perspective for precision diagnostics and therapeutic strategies.
Baoyuan Zhu, Shuhao Chen, Yunheng Diao, Wei Wang, Yuanyuan Huang, Liqin Liang, Xiaodan Lu, Rui Han, Minxin Guo, Zhaobo Li, Shuhong Wang, Hehua Li, Chenyu Liu, Jing Zhou, Dongsheng Xiong, Xiaobo Li, Yuping Ning, Xuetao Shi, Fengchun Wu, Kai Wu   +19 more
wiley   +1 more source

Spatial and Temporal Analysis of Climatic Zones in Kazakhstan Using Google Earth Engine

ISPRS International Journal of Geo-Information
Kazakhstan, located in Central Asia, is experiencing faster warming than the global trend, making it an important region regarding the study of how climate change is affecting climatic zones.
Kalamkas Yessimkhanova, Mátyás Gede
doaj   +1 more source

BLADE‐ON‐PETIOLE Genes Enable Genetic Bottleneck Mitigation Through Cross‐Species Repurposing of Floral Persistence Traits

Advanced Science, EarlyView.
This study shows that BLADE‐ON‐PETIOLE (BOP) proteins regulate floral abscission and senescence in tomato by interacting with TFAM1 to form transcriptional condensates controlling the ARABIDOPSIS THALIANA HOMEOBOX GENE 1 (ATH1)‐mediated abscission pathway.
Nan Xiao, Qianwen Lyu, Tinghao Zhang, Yupan Zou, Yue Xie, Dandan Yang, Cao Xu, Xiaozhen Huang   +7 more
wiley   +1 more source

Mainstreaming the local climate zone framework for climate-resilient cities

Nature Communications
The local climate zone framework is valuable for building climate-resilient cities but is limited in application. This limitation can be resolved by addressing three aspects: transdisciplinary dialog, global atlas construction, and cost–benefit assessment.
Jun Yang, Wenbo Yu, Alexander Baklanov, Baojie He, Quansheng Ge   +4 more
openaire   +4 more sources

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

Advanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun   +9 more
wiley   +1 more source

Interpretable machine learning analysis of environmental characteristics on bacillary dysentery in Sichuan Province

Frontiers in Public Health
BackgroundBacterial dysentery (BD) is a leading cause of diarrhea-related mortality globally, with its incidence heavily influenced by environmental factors.
Yao Zhang, Qiao-Lin Wang, Wei Peng, Meng-Yuan Zhang, Yao Qin, Lun Zhang, Rong-Jie Wei, Dian-Ju Kang   +7 more
doaj   +1 more source