Islatravir‐loaded dissolving microarray patches (MAPs) provide a minimally invasive, long‐acting solution for HIV‐1 prevention and treatment. In rats, sustained islatravir delivery lasts up to three months, while in minipigs, efficacious plasma levels are detected for six days.
Qonita Kurnia Anjani+11 more
wiley +1 more source
Neotropical moss floras : species common to North and South America [PDF]
North and South America share about 675 species that show two basic patterns, namely, those with a continuous range and those with a disjunct distribution.
Delgadillo M., Claudio
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Evolution of energy and nutrient supply in Zambia (1961-2013) in the context of policy, political, social, economic, and climatic changes. [PDF]
Kapulu NP+5 more
europepmc +1 more source
A flexible electrode loaded with a carbon nanowire network (CC@C‐NWN) is developed for electrochemically generating reactive chlorine species (RCS) from abundant chloride ions in body fluids for tumor therapy. CC@C‐NWN enhances chlorine evolution, inducing redox dysregulation and synergistic apoptosis‐ferroptosis in tumor cells.
Cuinan Jiang+10 more
wiley +1 more source
The influence of variations in ozone concentration on the temperature regime of the atmosphere [PDF]
The results of a study of the effects provided by changes in the concentration of atmospheric ozone on the mean temperatures of the troposphere and lower stratosphere are presented.
Rakipova, L. R.
core +1 more source
Reproductive seasonality in the Baka Pygmies, environmental factors and climatic changes. [PDF]
Piqué-Fandiño L+3 more
europepmc +1 more source
Rational Design of Unsaturated, Thioether Ionizable Lipids for Enhanced In Vivo mRNA Delivery
Lipid nanoparticles (LNPs) have rapidly become the delivery system of choice for RNA therapeutics. Here, a rational design approach is taken to improve the effectiveness of LNPs based on an ionizable thioether lipid library. The incorporation of unsaturated tails and bulkier, hydrophobic head groups significantly enhances their functionality and ...
Eleni Samaridou+4 more
wiley +1 more source
Climatic Change. Harlow Shapley Harvard University Press (London, Geoffrey Cumberlege, Oxford University Press), 1953. x11+318 pages, 58 illustrations. Price 48 shillings. [PDF]
G. C. Simpson
openalex +1 more source
Mitigating Climatic Changes Through Emission Reduction Technology [PDF]
This paper considers the role of technology in emission reduction strategies. This includes carbon sequestration, use of renewable emission- free and environmentally friendly energy sources, energy conservation efficiency, atmospheric variability ...
Ilaboya, I.R., Wara, S.T.
core