Results 21 to 30 of about 127,629 (315)

Physical-geographical aspects of formation of artificial firn-ice massives

Лëд и снег, 2015
The paper presents results of analysis of diurnal and potentially possible efficiency of water freezing aimed at construction of artificial infiltration (firn-ice) masses on the Russia’s territory.
A. V. Sosnovsky, P. R. Nakalov, S. V. Nenashev   +2 more
doaj   +1 more source

Summer Lake Destratification Phenomenon: A Peculiar Deep Lake on the Tibetan Plateau

Frontiers in Earth Science, 2022
Lake water temperature and the related thermal structure influence not only the provision of ecosystem services in lacustrine environments but also the interactions with regional climate. However, continuous lake temperature monitoring across the Tibetan
Rongmingzhu Su, Rongmingzhu Su, Zhipeng Xie, Weiqiang Ma, Weiqiang Ma, Weiqiang Ma, Yaoming Ma, Yaoming Ma, Yaoming Ma, Yaoming Ma, Yaoming Ma, Yaoming Ma, Binbin Wang, Wei Hu, Wei Hu, Zhongbo Su   +15 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Evaluation of lodgepole pine (Pinus contorta Dougl. ex Loudon) on a provenance plot situated in a formerly air-polluted area of the Krušné hory Mts. at the age of 34 years

Journal of Forest Science, 2018
The article evaluates 27 provenances of three subspecies of lodgepole pine on the Kovářská research plot (Krušné hory Mts.). The plot is part of a series of three established plots in various stand conditions.
Jiří ČÁP, Petr NOVOTNÝ, Martin FULÍN, Jaroslav DOSTÁL, František BERAN   +4 more
doaj   +1 more source

Development of Solontsovskie Lakes as indicator of humidity within Central Sikhote-Alin in the Late Holocene

Геосистемы переходных зон, 2021
The stages of development of small Solontsovskie (Shanduyskie) Lakes located in the middle mountains of the Central Sikhote-Alin within large landslides, formed on the slopes of the paleovolcano, are identified on the basis of complex study of the ...
Nadezhda G. Razjigaeva, Larisa A. Ganzey, Tatiana A. Grebennikova, Tatiana A. Kopoteva, Mikhail A. Klimin, Marina S. Lyashchevskaya, Alexander M. Panichev, Khikmatulla A. Arslanov, Fedor E. Maksimov, Aleksey Yu. Petrov   +9 more
doaj   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

FMI 5000: Um projecto sobre mudanças ambientais holocénicas [PDF]

Finisterra - Revista Portuguesa de Geografia, 2011
FMI 5000. A project on the environmental changes during the holocene.This paper presents the aims, the proposed methodology and the cases to be studied within the FMI 5000 – Environmental Changes: Fluvio‑marine interactions over the last 5000 years ...
Ana Ramos-Pereira, et al.
doaj  

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source