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Climate Change and Climate Science [PDF]

Science, 2004
T here is a paradoxical gulf between the importance of Earth's climate and the level of public interest in it. To be sure, tornadoes, killer heat waves, and floods make the headlines, but it's important to remember that weather is not climate. Some of the public's confusion may relate to a certain failure to make that distinction, as in the occasional ...
openaire   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Review of WRF for weather and climate change over the Tibetan Plateau

Advances in Climate Change Research
The state-of-the-art Weather Research and Forecasting Model (WRF) is an indispensable tool for studying weather and climate change; however, its application over the Tibetan Plateau—a region characterized by high altitude and complex topography—remains ...
Lian Liu, Xin-Zhong Zhang, Yao-Ming Ma
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Climate change perceptions and adaptation by Sebei pastoralists in Mount Elgon, Uganda: a qualitative survey

Journal of Ethnobiology and Ethnomedicine
Background Pastoralists’ sedentarisation and agriculturalisation might increase their vulnerability to climate change impacts, but few studies have investigated if this is the case in mountain areas.
Siya Aggrey, Elsa Varela, Rodrigue Batumike, Aida Cuni-Sanchez   +3 more
doaj   +1 more source

Extreme precipitation detection ability of four high-resolution precipitation product datasets in hilly area: a case study in Nepal

Advances in Climate Change Research
Given Nepal's vulnerability to extreme precipitation (EP), it is imperative to conduct a comprehensive analysis to comprehend the historical trends of such events.
Sunil Subba, Yao-Ming Ma, Wei-Qiang Ma, Cun-Bo Han   +3 more
doaj   +1 more source

Influence of meteorological factors, snow properties and climatic changes on evaporation from the snow cover surface

Водное хозяйство России: проблемы, технологии, управление, 2023
The contribution of evaporation from the surface of the snow cover to the water balance of the land surface is a little-studied area of hydrology. Th e growing relevance of these studies increases with climate warming and more active involvement of the ...
Sergey A. Lavrov
doaj   +1 more source

A description on decadal changes in warm season average of precipitation over the Caspian coast of Iran territory [PDF]

تحقیقات کاربردی علوم جغرافیایی, 2022
Change in precipitation features is one of climate change outcome. Change in precipitation amount, especially in warm season, may influences climato-environmental phenomenon as well as human activity.
Hossein Asakereh, nasrin varnaseri ghandali   +1 more
doaj  

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

A decadal trend of juvenile European sea bass (Dicentrarchus labrax, L.) responses to climate patterns in the Mondego estuary, Portugal

Frontiers in Marine Science, 2015
Estuarine systems support the life cycle stages of commercially important marine fish and are influenced by large and local-scale climatic patterns. Also, extreme events triggered by climate changes may influence the functioning of nursery grounds and ...
Eduardo Granja Bento
doaj   +1 more source