Results 51 to 60 of about 657,952 (309)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Spatiotemporal Variation in Water Yield and Their Underlying Mechanisms in Tarim River Basin

Guan'gai paishui xuebao, 2021
【Objective】 Global climate change and anthropogenic activities combine to have altered water flow and distribution in many basins, especially those in arid and semi-arid regions. Understanding water yield and its spatiotemporal change in a basin, as well
SUN Qi, XU Changchun, REN Zhengliang, CHU Zhi   +3 more
doaj   +1 more source

Importance of Soil Quality in Environment Protection [PDF]

, 2007
Soil quality can be characterised by the harmony between it’s physical and biological state and the fertility. From the practical crop production viewpoint, some important contrasting factors of soil quality are: (1) soil looseness – compaction; (2 ...
Birkás, Márta, Bottlik, László, Kalmár, Tibor, Takács, Tamás   +3 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

The exotic invasive plant Vincetoxicum rossicum is a strong competitor even outside its current realized climatic temperature range [PDF]

, 2013
Dog-strangling vine (Vincetoxicum rossicum) is an exotic plant originating from Central and Eastern Europe that is becoming increasingly invasive in southern Ontario, Canada.
Antunes, Pedro M., Sanderson, Laura A.
core   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Climatic trends and its impact on rice production in different agroclimatic zones of West Bengal, India

Journal of Agrometeorology
Changing climate has become one of the major perils for agriculture throughout the world. Rice is one of the most important food grains in India. In this study, the effect of climatic factors on rice production of different agroclimatic zones and ...
ROHIT PRAMANICK , BISWAJIT PAL
doaj   +1 more source

Predicting incidence of Crimean-Congo hemorrhagic fever using satellite monitoring (remote sensing) data in the Stavropol Territory

Журнал микробиологии, эпидемиологии и иммунобиологии, 2022
Introduction. With the epidemiological situation for Crimean-Congo hemorrhagic fever (CCHF) remaining tense in many countries worldwide, special attention should be focused on development and improvement of risk-based epidemiological prediction methods ...
V. M. Dubyanskiy, D. A. Prislegina, A. E. Platonov   +2 more
doaj   +1 more source

Adapting to climate change: an evolving research programme [PDF]

, 2010
Since its launch in 1977, the scientific issues addressed by papers published in Climatic Change have changed considerably. Nuclear winter came and went, and papers have come from an increasingly diverse range of disciplines. Most obvious, of course, has
Arnell, Nigel William
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source