Results 91 to 100 of about 391,518 (330)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Progress Toward Zero: The Climb to Sustainability - Interview with Ray Anderson [PDF]

, 2012
Overhauling a wasteful and polluting company takes insight, knowledge, commitment, and courage. In this quest to achieve total sustainability by producing its product with no carbon emissions or landfill matter, Interface is well on its way to its 2020 ...
Gingerich, Elizabeth
core   +2 more sources

iPhone Sensors in Tracking Outcome Variables of the 30-Second Chair Stand Test and Stair Climb Test to Evaluate Disability: Cross-Sectional Pilot Study

JMIR mHealth and uHealth, 2017
BackgroundPerformance tests are important to characterize patient disabilities and functional changes. The Osteoarthritis Research Society International and others recommend the 30-second Chair Stand Test and Stair Climb Test, among others, as core tests
Adusumilli, Gautam, Joseph, Solomon Eben, Samaan, Michael A, Schultz, Brooke, Popovic, Tijana, Souza, Richard B, Majumdar, Sharmila   +6 more
doaj   +1 more source

Exploring Candidate Selection Processes in the UK: Climbing the ‘Political Glass Cliff’

, 2023
Hiroko TAKEDA
openalex   +2 more sources

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

CLIMB [PDF]

, 2013
La strategia di CLIMB è volta ad utilizzare ed integrare tecniche avanzate di monitoraggio sul campo, telerilevamento a distanza, confronto incrociato e verifica di modelli climatici, modellistica idrologica integrata e valutazione dei fattori socio ...

core  

Energy Absorption Characteristics and Parameter Optimization of Anti-Climb Energy-Absorbing Devices for Subway Vehicles under Impact Loads

Applied Sciences
To further enhance the crashworthiness of subway vehicle anti-climb energy-absorbing devices, this paper proposes a novel collapsible structure, which is embedded with honeycomb aluminum blocks and consists of an inner and outer double-layer square tube.
Yuru Li, Hao Zhang, Junke Xie, Shoune Xiao, Tao Zhu, Gangjian Zhou, Liyou Xu   +6 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Climbing [PDF]

Prairie Schooner, 2020
  +5 more sources