Results 111 to 120 of about 391,518 (330)

Advanced Supersonic Technology concept AST-100 characteristics developed in a baseline-update study [PDF]

open access: yes
The advanced supersonic technology configuration, AST-100, is described. The combination of wing thickness reduction, nacelle recontouring for minimum drag at cruise, and the use of the horizontal tail to produce lift during climb and cruise resulted in ...
Baber, H. T., Jr., Swanson, E. E.
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Climbing the Entrepreneurial Ladder: The Role of Gender [PDF]

open access: yes
We investigate whether women and men differ with respect to the steps they take in the entrepreneurial process, distinguishing between five successive steps described by the following positions: (1) "never thought about it"; (2) "thinking about starting ...
Grilo, I.   +3 more
core   +1 more source

Review of Armed Offenders Squad and Special Tactics Group fitness policy for the New Zealand Police : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Exercise and Sport Science at Massey University, Wellington, New Zealand [PDF]

open access: yes, 2015
Phase One: Web based survey questionnaire. Recruitment into the New Zealand Police’s Armed Offenders Squad [AOS] and Special Tactics Group [STG] depends on successful completion of selection courses, as detailed in their respective physical fitness ...
Dickie, James Alexander
core  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Characteristics of constrained optimum trajectories with specified range [PDF]

open access: yes
Necessary conditions of optimality are derived for trajectories whose structure is limited to climb, steady cruise, and descent segments. The performance function consists of the sum of fuel and time costs, referred to as direct operating cost (DOC). The
Erzberger, H., Lee, H.
core   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

open access: yesMolecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard   +12 more
wiley   +1 more source

Customers Suffer From Employee Churn: High Turnover Makes It Harder to Provide Top Service [PDF]

open access: yes, 2009
Key Findings: • As rates of voluntary turnover climb within key business units, customers are more likely to report bad customer service. • When new workers arrive, established workers have to take time away from customer service to train the
Center for Advanced Human Resource Studies, ILR School, Cornell University.
core   +1 more source

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