Results 171 to 180 of about 391,518 (330)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Improvements in health-related quality of life in patients with transfusion-dependent β-thalassemia after exagamglogene autotemcel. [PDF]

Blood Adv
Fuente J, Frangoul H, Lang P, Wall D, Meisel R, Corbacioglu S, Li AM, Shah AJ, Carpenter B, Kwiatkowski JL, Mapara MY, Liem RI, Rupprecht J, Kuo KHM, Merkeley H, Algeri M, Smith W, Kohli P, Li N, Rubin J, Zhang S, Hobbs W, Locatelli F.   +22 more
europepmc   +1 more source

2P2-D14 Realization of automatic step climbing by Wheeled Robot HANZO with Variable Structure Functionality using 3D range sensor

, 2006
Naoji Shiroma, Yusuke Fujino, Fumitoshi Matsuno   +2 more
openalex   +2 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Can Motivation and Self-Efficacy Predict a Law Enforcement Officer's General and Job-Specific Fitness? [PDF]

Int J Exerc Sci
Lockie RG, Beitzel MM, Campana T, Kramer J, Orr RM, Dawes JJ, Dulla JM.   +6 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Small Molecule Modulation of MHC-I Surface Expression: A Click Chemistry-Based Discovery Approach. [PDF]

J Med Chem
Newkirk SE, Kelly JJ, Chordia MD, Dou Y, Zhang T, Pires MM.   +5 more
europepmc   +1 more source

CHEMICAL CONTROL OF CLIMBING MIMOSA IN A LOCAL PASTURE

, 1988
Lii-Chyuan Liu, Greisha Sievens
openalex   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Analysis of physical fitness tests for police officers in various countries: a scoping review. [PDF]

Front Physiol
Zhang Z, He J, Zhang X, Zhao L, Deng Y.
europepmc   +1 more source