Results 181 to 190 of about 391,518 (330)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

<i>E. coli</i> chemosensing accuracy is not limited by stochastic molecule arrivals. [PDF]

Nat Phys
Mattingly HH, Kamino K, Ong J, Kottou R, Emonet T, Machta BB.   +5 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Clemente et al JEB Northern Quoll climbing data set

, 2019
Christofer J. Clemente, Taylor J. M. Dick, Rebecca Wheatley, Skye F. Cameron   +3 more
openalex   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Toward a Dynamic Vertical Climbing Robot

, 2006
Jonathan E. Clark, Daniel I. Goldman, Tao S. Chen, Robert J. Full, Daniel E. Koditschek   +4 more
openalex   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Effects of Climate Change on Takeoff Distance and Climb Rate; A Case Study: Boeing 737-800 Max Airplane

Havacılık ve Uzay Teknolojileri Dergisi
The inevitable increase in averageairtemperaturedue to global warming undoubtedly affects the aviation sector as well.The increase in maximum and average air temperatures has a significant effect on the weight and fuel intake for ...
Şeyda Yalçınkaya Çağlıyan, Deniz Demirhan   +1 more
doaj  

Performance of the SARC-F (Strength, Assistance Walking, Rise From a Chair, Climb Stairs, and Falls) Questionnaire for Sarcopenia Screening in Patients With End-Stage Renal Disease on Hemodialysis. [PDF]

Cureus
Dehesa-Lopez E, Ramírez-Sosa D, Sosa-Guerrero S, Lopez-Moreno F, Curiel-González MF, Araujo-Rocha E.   +5 more
europepmc   +1 more source

Electromyographic Analysis of the Femoral Muscle before and after a Mountain-climbing Race

, 2014
Yujiro Masu, Tatsuya Kasuyama, Seiji KAWATO, Ken Muramatsu, Tomoyasu Ishiguro   +4 more
openalex   +2 more sources