Results 111 to 120 of about 156,233 (296)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

ROCKMIND: Multimodal neurophysiological assessment of grip force control and fatigue in sport climbing

Current Directions in Biomedical Engineering
Introduction. Sport climbing performance critically depends on sustaining submaximal grip forces under fatigue while maintaining precise force control. From a neurophysiological perspective, this process requires coordinated recruitment of motor units in
Semeia Lorenzo, Brümmer Tim, Bulling Philipp, Taher Idell Mohamed, Nguyen Anh Zoe, Klotz Thomas, Röhrle Oliver, Marquetand Justus   +7 more
doaj   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Analysis of Lower Limb Performance Determinants in Sport Climbing

Applied Sciences
Sport climbing has evolved into a demanding discipline where lower limb performance is increasingly relevant, particularly in indoor bouldering. This exploratory study aimed to identify trends in strength and flexibility variables of the lower limbs in ...
Fabio García-Heras, María Diez-Martín, Diego González-Martín, Jorge Gutiérrez-Arroyo, Olga Molinero, Alfonso Salguero   +5 more
doaj   +1 more source

A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi, Giorgio Ricciardiello Mejia, Andre Metzger, Kang Hyun Ryu, Salonee Marwaha, Eva Grzegorczyk, Li Zhou, Eliana Jacobs, Boris Gilyadov, Claudia Kunney, Liqhwa Ncube, Ankit Parekh, Emmanuel Mignot, Fanny M. Elahi, Joseph Winer, Kathleen Poston, Andreas Brink‐Kjaer, Emmanuel H. During   +17 more
wiley   +1 more source

DESIGN OF MULTI-TERRAIN CLIMBING ROBOT FOR PETROCHEMICAL APPLICATIONS

, 2012
A multi-terrain climbing robot provides more flexibility while doing inspection in scenarios where the environments comprise several types of landscape such as walls, steps, ceiling, and sloped ferromagnetic surfaces.
Virk, Gurvinder S.,, Kumar, John Sujith,, Kamagaluh, Braisa,   +2 more
core  

Subclinical Optic Nerve Involvement in Radiologically Isolated Syndrome: Multimodal Detection and Diagnostic Impact

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We aimed to determine the frequency of subclinical optic nerve (ON) lesions using MRI, optical coherence tomography (OCT), and visual evoked potentials (VEP) in radiologically isolated syndrome (RIS), and to assess their diagnostic and prognostic significance.
Christine Lebrun‐Frenay, Cassandre Landes‐Château, Lydiane Mondot, Mikael Cohen, Margherita Popolo, Jérôme de Seze, Bertrand Bourre, Françoise Durand‐Dubief, Olivier Casez, Orhun H. Kantarci, Aksel Siva, Stephanie Baillif, Darin T. Okuda, Letizia Leocani   +13 more
wiley   +1 more source

Using the Own Flexibility of a Climbing Robot as a Double Force Sensor [PDF]

, 2011
Force sensors are used when interaction tasks are carried out by robots in general, and by climbing robots in particular. If the mechanics and electronics systems are contained inside the own robot, the robot becomes portable without external control ...
Morón Fernández, Carlos, Morales Cabrera, Rafael, Somolinos Sánchez, José Andrés, García García, Alfonso   +3 more
core  

A parallel approach to row-based VLSI layout using stochastic hill-climbing [PDF]

, 2003
Parallel algorithms based on stochastic hill-climbing and parallel algorithms based on simple elements of a genetic algorithm for the one-sided bipartite crossing number problem, used in row-based vlsi layout, were investigated. These algorithms were run
Ondrej Sykora (7168337), Mark S. Withall (7168622), Matthew Newton (7169372), Imrich Vrt'o (7168520)   +3 more
core   +1 more source

Features of cognitive productivity of children in competitive and recovery periods. [PDF]

Pedagogìka, Psihologìâ ta Mediko-bìologìčnì Problemi Fìzičnogo Vihovannâ ì Sportu, 2011
Features of mental capacity of children of secondary school age in a competitive activity. A psycho diagnostic examination of children of school age (10-15 years) has been systematically engaged in rock climbing.
Gant Н.E.
doaj