Results 111 to 120 of about 105,706 (296)

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

What contribution can residential field courses make to the education of 11-14 year-olds? [PDF]

, 2006
In this article we evaluate the effects that residential field courses had for 428 KS3 (11-14 year-old) students from 10 London schools in 2004. Teachers and students reported that levels of motivation and participation were very high, particularly where
Amos, Ruth, Reiss, Michael
core   +1 more source

Monitoring of the Community of Scandent Weeds in Yerba Mate (Ilex paraguariensis A. St. Hil., Aquifoliaceae) cultivated in North-Eastern Argentina

Revista de la Facultad de Ciencias Agrarias
Perennial crops account for 10% of the world’s cultivated area. In Argentina, yerba mate is grown within complex plant communities where scandent weeds are major challenges.
Claudio Marcos Dávalos, Rafael Augusto Lovato Echeverría, Laura Itatí Giménez, María Gabriela López   +3 more
doaj  

Rock climbing activity and physical habitat attributes impact avian community diversity in cliff environments.

PLoS ONE, 2019
As the sport of outdoor rock climbing rapidly grows, there is increasing pressure to understand how it can affect communities of organisms in cliff habitats.
Nora Covy, Lauryn Benedict, William H Keeley   +2 more
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Production of organic seed for the organic sector (OF0154) [PDF]

, 2000
This is the final report of Defra project OF0154. Under the European Union Regulation on the organic production of agricultural products (2092/91), crops raised in organic systems should be grown from organically produced seed or vegetative material ...
Wolfe, Prof Martin
core  

Design and optimal springs stiffness estimation of a Modular OmniCrawler in-pipe climbing Robot

, 2017
This paper discusses the design of a novel compliant in-pipe climbing modular robot for small diameter pipes. The robot consists of a kinematic chain of 3 OmniCrawler modules with a link connected in between 2 adjacent modules via compliant joints. While
Krishna, K. Madhava, Sachdeva, Enna, Sarkar, Abhishek, Singh, Akash   +3 more
core   +1 more source