Results 61 to 70 of about 51,559 (249)

Impact of Mechanistic Modeling and Simulation Methodologies on Product‐Specific Guidance Development for Non‐Orally Administered Drug Products

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT The U.S. Food and Drug Administration (FDA) publishes product‐specific guidances (PSGs), with bioequivalence (BE) recommendations for prospective generics. Developing BE recommendations for non‐orally administered drug products including long‐acting injectables (LAI), orally inhaled drug products, and drugs applied locally to the skin ...
Steven G. Chopski, Ross L. Walenga, Ming‐Liang Tan, Khondoker Alam, Andrew Babiskin, Lanyan Fang, Eleftheria Tsakalozou   +6 more
wiley   +1 more source

Two Ulcers on the Chin That Developed After Fever: Quiz Case

JEADV Clinical Practice, EarlyView.
Viktor Capiau, Sofie Engelen, An Van Laethem, Francesca Bosisio   +3 more
wiley   +1 more source

Suspected congenital oesophageal stenosis in a cat

Veterinary Record Case Reports, EarlyView.
Abstract A 6‐week‐old, female, British shorthair cat was presented with a 4‐week history of regurgitation and a 2‐day history of cough and dyspnoea. Thoracic radiographs revealed an alveolar pattern suggestive of pneumonia secondary to regurgitation, and antibiotic therapy was initiated. After identifying a smooth stenosis with no signs of inflammation
Charline Fauquet, Patricia Meynaud, Caroline Didier, Fabrice Conchou, Tiphaine Blanchard, Rachel Lavoué, Armelle Diquélou   +6 more
wiley   +1 more source

Prevention and treatment of bacterial vaginosis in pregnant women with isthmic-cervical insufficiency

Репродуктивная эндокринология, 2020
Purpose of the study was to evaluate the effectiveness of clindamycin in combination with metronidazole and miconazole in complex therapy in pregnant women suffering from vaginal dysbiosis with ischemic-cervical insufficiency with threat of premature ...
Т. Г. Романенко, О. М. Суліменко   +1 more
doaj   +1 more source

Exposure to Systemic Antimicrobials During Pregnancy and Risk of Miscarriage: A Population‐Based Registry Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To estimate miscarriage risk following gestational antimicrobial exposure while addressing biases that have affected previous studies. Design Population‐based cohort study. Setting Linkage of four nationwide registries: Medical Birth Registry of Norway (MBRN), Norwegian Prescribed Drug Registry (NorPD), Norwegian Patient Registry ...
Thomas Boissiere‐O'Neill, Marleen M. H. J. van Gelder, Hilde M. Engjom, Hedvig M. E. Nordeng   +3 more
wiley   +1 more source

Chiral Alkyl Halides: Underexplored Motifs in Medicine

Marine Drugs, 2016
While alkyl halides are valuable intermediates in synthetic organic chemistry, their use as bioactive motifs in drug discovery and medicinal chemistry is rare in comparison. This is likely attributable to the common misconception that these compounds are
Bálint Gál, Cyril Bucher, Noah Z. Burns   +2 more
doaj   +1 more source

Plantar Nodular Lesion in A 22‐Year‐Old Immunocompetent Female Patient

JEADV Clinical Practice, EarlyView.
Ariana Ramírez‐Zumbado, Daniel Barquero‐Orias, Wendy Vindas‐Calderón, Paula Forsythe‐Rodríguez   +3 more
wiley   +1 more source

Clinical Characteristics of a Canadian Cohort of Hidradenitis Suppurativa

JEADV Clinical Practice, EarlyView.
Lily Acheampong, David Croitoru, Marissa Joseph, Raed Alhusayen, Nesrine Brahimi, Vincent Piguet   +5 more
wiley   +1 more source

Clinician's Approach to Antibiotic Treatment and Management of Preterm Prelabour Rupture of Membranes (PPROM) in Australia and Aotearoa New Zealand—A Survey

Australian and New Zealand Journal of Obstetrics and Gynaecology, EarlyView.
ABSTRACT Background Preterm prelabour rupture of membranes (PPROM) is a common obstetric complication with significant maternal and foetal consequences. There is a lack of contemporary evidence regarding the optimal management of PPROM, including the best antibiotic regimen and management at previable gestations.
Sonia Kua, Amanda Poprzeczny, Katie Groom, Matthew Payne, John Newnham, Brett Manley, Clare L. Whitehead   +6 more
wiley   +1 more source

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome associated with cefotaxime and clindamycin use in a 6 year-old boy: a case report

The Pan African Medical Journal, 2017
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare and potentially life-threatening idiosyncratic drug reaction. It presents with extensive rash, fever, lymphadenopathy, hematologic abnormalities (eosinophilia and/or ...
Burcu Karakayalı, Ahmet Sami Yazar, Deniz Çakir, Aysen Cetemen, Mandana Kariminikoo, Burak Deliloglu, Sirin Guven, Ismail Islek   +7 more
doaj   +1 more source