Results 241 to 250 of about 4,099,787 (356)

Help Wanted - Confronting the health care worker crisis to expand access to HIV/AIDS treatment: MSF's experience in southern Africa [PDF]

, 2007
MSF Brussels, MSF South Africa
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

FastPrEP: a protocol to evaluate uptake, coverage, and effectiveness of a youth-focused, decentralised and differentiated district-wide HIV pre-exposure prophylaxis program. [PDF]

BMC Public Health
Rousseau E, Davey DJ, Fynn LS, Wallace M, Macdonald P, Pike C, Mathola N, Little F, Lebelo K, Bekker LG.   +9 more
europepmc   +1 more source

In Practice, v. 11, no. 1, fall 2010 [PDF]

, 2010

core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Surgical capacity in ophthalmology: the unmet need for sustainable solutions. [PDF]

Eye (Lond)
Hillier RJ, Chang A, Matse-Orere A, Bindesbøll C, Moniz LS, Heaton V, Petrie J, Bannister C.   +7 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Examining the changing demand for orthotic service provision from routinely collected digital patient data: A national retrospective descriptive study across three clinics in Cambodia. [PDF]

PLoS One
Spurway C, Dickinson A, Gates L, Metcalf C, Kheng S, Harte C, Sam B, Simpson S, Channon A.   +8 more
europepmc   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Bridging Hypertension Care Shortfalls Between Provider Capacity and Patient Needs: A Pooled Analysis of Data From 199 Countries and Territories. [PDF]

Hypertension
Mishra SR, Satheesh G, Khanal V, Adhikari B, Parker D, Picone DS, Chapman N, Schutte AE, Lindley RI.   +8 more
europepmc   +1 more source