Results 141 to 150 of about 10,946,773 (345)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Gross anatomy in familiar medicine and in the clinical courses of medical studies
, 2002 The aim of this work was to highlight the gross anatomy knowledge necessity that familiar physicians and clinical courses students have. At the same time, it was our interest to know their suggestions about the discipline Humana Gross Anatomy in Medical
Pérez L. +1 more
core
Blood supply to the human spinal cord: Part I. Anatomy and hemodynamics
, 2015 The arterial network that supplies the human spinal cord, which was once thought to be similar to that of the brain, is in fact much different and more extensive.
Marios Loukas +9 more
core +1 more source
Clinical anatomy of the pelvic floor
Acta chirurgica Iugoslavica, 2006 The pelvic floor forms the supportive and caudal border of the human?s abdominopelvic cavity. A detailed anatomical understanding of its complex architecture is mandatory for the pelvic floor surgeon (general surgeon, gynaecologist and urologist) and for fundamental mechanisms of anorectal as well as urogenital dysfunctions as different anatomical ...
openaire +3 more sources
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
The gross anatomy of the renal sympathetic nerves revisited
, 2016 Catheter-based renal denervation techniques focus on reducing blood pressure in resistant hypertension. This procedure requires exact knowledge of the anatomical interrelation between the renal arteries and the targeted renal nervous plexus.
Sanudo, Jose +9 more
core +1 more source
Utility of the Anatomage Virtual Dissection Table in Creating Clinical Anatomy and Radiology Learning Modules. [PDF]
Adv Med Educ Pract, 2023 Chaudhry H +15 more
europepmc +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
The meta-analysis and systematic review of prevalence and clinical anatomy of the arc of Buhler. [PDF]
Sci Rep, 2023 Kowalczyk KA +4 more
europepmc +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source