Results 241 to 250 of about 874,306 (301)
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
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Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
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Aging and Cancer, EarlyView.This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel +4 more
wiley +1 more source
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Clinical cerebrovascular anatomy
Catheterization and Cardiovascular Interventions, 2010AbstractStroke is often the result of carotid atheroma, which may cause ischemia via progressive arterial narrowing or lead to superimposed thrombus formation and subsequent atheroembolism to the intracerebral vasculature. Revascularization through carotid endarterectomy or carotid artery stenting with embolic protection devices has produced favorable ...
Amar, Krishnaswamy +2 more
openaire +2 more sources
1999
An understanding of the relevance of anatomy to clinical practice is fundamental for medical students and young doctors. For this reason most of the questions in this self-assessment book are presented as case histories or clinical puzzles that require anatomical information for their elucidation.
Edward Evans +3 more
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An understanding of the relevance of anatomy to clinical practice is fundamental for medical students and young doctors. For this reason most of the questions in this self-assessment book are presented as case histories or clinical puzzles that require anatomical information for their elucidation.
Edward Evans +3 more
openaire +1 more source
Chromosomes and clinical anatomy
Clinical Anatomy, 2016Chromosome abnormalities may cast light on the nature of mechanisms whereby normal anatomy evolves, and abnormal anatomy arises. Correlating genotype to phenotype is an exercise in which the geneticist and the anatomist can collaborate. The increasing power of the new genetic methodologies is enabling an increasing precision in the delineation of ...
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Diastasis Recti: Clinical Anatomy
Plastic and Reconstructive Surgery, 2008Enduring diastasis repair is one of the yardsticks by which a successful abdominoplasty is measured, because the presence and size of diastasis recti are thought to be reliable indicators of abdominal wall laxity and protrusion. The author's study of the "normal" anatomy of diastasis challenges these concepts about diastasis recti.Ninety-two ...
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2018
The globe lies in the orbit, a pyramidal bony cavity nestled in the facial skeleton. It is implanted in fat, but separated from it by a membranous sac named Tenon’s capsule. Its attachments include the corneoscleral junction anteriorly and the optic nerve posteriorly. Tenon’s capsule is penetrated by the tendons of the extraocular muscle.
Maram A. Elsayed, Igor Kozak
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The globe lies in the orbit, a pyramidal bony cavity nestled in the facial skeleton. It is implanted in fat, but separated from it by a membranous sac named Tenon’s capsule. Its attachments include the corneoscleral junction anteriorly and the optic nerve posteriorly. Tenon’s capsule is penetrated by the tendons of the extraocular muscle.
Maram A. Elsayed, Igor Kozak
openaire +1 more source