Results 161 to 170 of about 28,392,673 (339)
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Skin manifestation of gastric cancer (clinical case)
Современная наука и инновацииDermatological reactions are one of the most common manifestations of the paraneoplastic process. Paraneoplastic syndromes include non-oncological diseases that arise under the influence of hormones nd biologically active substances secreted by the tumor.
Yu. A. Dykhno +2 more
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FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
COMPLEX CLINICAL SCENARIOS IN ABDOMINAL SURGERY: A CASE REPORT
Паёми СиноThis article describes a clinical case involving the successful repair of a giant postoperative hernia in the anterolateral abdominal wall of a female patient.
Bokiev Fatkhullo Bakhhshuloevich +3 more
doaj +1 more source
Vaginismus and Dyspareunia. A Case Report From Clinical Practice
Психологічне консультування i психотерапіяThe article deals with the following clinical case. Female patient Z., 27 years old, not married, currently has no sexual partner. For 2 years she has had muscle contractions that prevent the penis from entering the vagina, accompanied by contractions of
Garnik Kocharyan
doaj +1 more source
Clinical Cases - TOE clinical cases [PDF]
European Heart Journal - Cardiovascular Imaging, 2019 openaire +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Амбулаторная хирургия, 2016 Venous trophic ulcers are the result of serious circulatory disorders against a background of varicose or post-thrombotic disease of the lower extremeties. According to various authors, they complicate the course of chronic venous insufficiency in 15-18%
S. N. Yakushkin
doaj