Results 11 to 20 of about 175,553 (149)

CYP46A1 activation by low-dose efavirenz enhances brain cholesterol metabolism in subjects with early Alzheimer’s disease

Alzheimer’s Research & Therapy, 2022
Background Efavirenz is an anti-HIV drug, and cytochrome P450 46A1 (CYP46A1) is a CNS-specific enzyme that metabolizes cholesterol to 24-hydroxycholesterol (24HC).
Alan J. Lerner, Steven E. Arnold, Erin Maxfield, Aaron Koenig, Maria E. Toth, Brooke Fortin, Natalia Mast, Bianca A. Trombetta, John Denker, Andrew A. Pieper, Curtis Tatsuoka, Sangeetha Raghupathy, Irina A. Pikuleva   +12 more
doaj   +1 more source

Distribution of Candida albicans and non-albicans Candida species isolated in different clinical samples and their in vitro antifungal suscetibity profile in Ethiopia

BMC Infectious Diseases, 2020
Background The spectrum of yeasts and their antifungal susceptibility profile are poorly known and treatment of fungal disease has remained empirical.
Elias Seyoum, Adane Bitew, Amete Mihret
doaj   +1 more source

Decreased Noise and Identification of Very Low Voltage Signals Using a Novel Electrophysiology Recording System

European Cardiology Review, 2023
Aims: The interpretation of intracardiac electrograms recorded from conventional electrophysiology recording systems is frequently impacted by powerline (50/60 Hz) noise and distortion due to notch filtering.
Josef Kautzner, Petr Peichl, Rune Paamand, Mark D Carlson   +3 more
doaj   +1 more source

Isolated Diastolic Hypertension and Kidney and Cardiovascular Outcomes in CKD: The Chronic Renal Insufficiency Cohort (CRIC) Study

Kidney Medicine, 2023
Rationale & Objective: The clinical significance of isolated diastolic hypertension in patients with chronic kidney disease (CKD) is unclear. We assessed the prevalence of isolated diastolic hypertension and its association with adverse kidney and ...
Saud Al Saleh, Mirela Dobre, Sarah DeLozier, Jaime Perez, Nirav Patil, Mahboob Rahman, Nishigandha Pradhan   +6 more
doaj   +1 more source

Oral immune dysfunction is associated with the expansion of FOXP3+PD-1+Amphiregulin+ T cells during HIV infection

Nature Communications, 2021
Anti-retroviral treatment does not fully resolve mucosal dysfunction and systemic inflammation in HIV infected individuals. Authors show here that an unusual population of regulatory T cells, distinguished by Amphiregulin expression and the incapability ...
N. Bhaskaran, E. Schneider, F. Faddoul, A. Paes da Silva, R. Asaad, A. Talla, N. Greenspan, A. D. Levine, D. McDonald, J. Karn, M. M. Lederman, P. Pandiyan   +11 more
doaj   +1 more source

Carbon Dioxide Monitoring Demonstrates Variations in the Quality of Ventilation on Public Transportation Buses and University Student Shuttle Vans and Identifies Effective Interventions

Pathogens and Immunity, 2023
Background: There is a risk for transmission of severe acute respiratory syndrome 2 (SARS-CoV-2) and other respiratory viruses in motor vehicles, particularly if ventilation is inadequate.
David Henry Greentree, Brigid M Wilson, Curtis J Donskey   +2 more
doaj   +1 more source

Antibiotic exposure and acquisition of antibiotic-resistant gram-negative bacteria among outpatients at a US Veterans Affairs medical center

Antimicrobial Stewardship & Healthcare Epidemiology, 2022
Objectives: To assess the prevalence of antibiotic-resistant gram-negative bacteria (R-GNB) among patients without recent hospitalization and to examine the influence of outpatient antibiotic exposure on the risk of acquiring R-GNB in this population ...
Ukwen C. Akpoji, Brigid M. Wilson, Janet M. Briggs, Sunah Song, Taissa A. Bej, Federico Perez, Robin L. P. Jump   +6 more
doaj   +1 more source

Demonstrating public health impacts of translational science at the clinical and translational science collaborative (CTSC) of northern Ohio: a mixed-methods approach using the translational science benefits model

Frontiers in Public Health
The Clinical and Translational Science Award (CTSA) program, funded by the National Center for Advancing Translational Sciences (NCATS), aims to accelerate the translation of research into public health impacts.
Lixin Zhang, Umut A. Gurkan, Kelli Qua, Shannon Swiatkowski, Sheree Hemphill, Clara M. Pelfrey   +5 more
doaj   +1 more source

Dosimetric Effect of Thymus and Thoracic Duct on Radiation-Induced Lymphopenia in Patients With Primary Lung Cancer Who Received Thoracic Radiation

Advances in Radiation Oncology, 2023
Purpose: Radiation-induced lymphopenia is a well-recognized factor for tumor control and survival in patients with cancer. This study aimed to determine the role of radiation dose to the thymus and thoracic duct on radiation-induced lymphopenia.
Jinliang Zhang, MD, Li Yang, MD, PhD, Hui Li, MD, PhD, Jeff W. Chan, MSc, Eric K.W. Lee, MSc, Min Liu, MD, Lingyu Ma, MSc, Qin Liu, MD, Jian-Yue Jin, PhD, Pingfu Fu, PhD, Zhiyuan Xu, MD, PhD, Feng-Ming (Spring) Kong, MD, PhD   +11 more
doaj   +1 more source

Impact of geographic distance on appraisal delay for active TB treatment seeking in Uganda: a network analysis of the Kawempe Community Health Cohort Study

BMC Public Health, 2018
Background Appraisal delay is the time a patient takes to consider a symptom as not only noticeable, but a sign of illness. The study’s objective was to determine the association between appraisal delay in seeking tuberculosis (TB) treatment and ...
Kyle Fluegge, LaShaunda L. Malone, Mary Nsereko, Brenda Okware, Christian Wejse, Hussein Kisingo, Ezekiel Mupere, W. Henry Boom, Catherine M. Stein   +8 more
doaj   +1 more source