Results 201 to 210 of about 2,986,872 (249)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Comparative Effectiveness of CagriSegma, Semaglutide, Cagrilintide and Tirzepatide in the Management of Overweight and Obesity: A Network Meta-Analysis of Randomized Clinical Trials. [PDF]

Endocrinol Diabetes Metab
Hamarsheh S, Jaber AR, Abu-Khazneh O, Andonie CR, Majadleh S, Zahran A, Ayesh H.   +6 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Progressive Resistance Training Combined with Neuromuscular Electrical Stimulation for Sarcopenic Dysphagia in Elderly Inpatients: A Retrospective Cohort Study in China. [PDF]

J Multidiscip Healthc
Ma J, Zhang H, Shu S, Qiu F, Chen H, Jiao X, Ma C, Ding X.   +7 more
europepmc   +1 more source

Absolute versus change in pulmonary vascular resistance in relation to European Society of Cardiology/European Respiratory Society risk change in pulmonary arterial hypertension. [PDF]

JHLT Open
Donker SCM, Wild CJB, Augustine DX, Suntharalingam J, Ross RVM, van Dijk APJ, Maxwell JD, Oxborough D, Thijssen DHJ.   +8 more
europepmc   +1 more source

Rate of decline in residual kidney function and cognitive impairment in incident haemodialysis patients: A prospective, longitudinal analysis of the BISTRO trial cohort. [PDF]

PLoS One
Rosenberg KL, Dasgupta I, Nitsch D, Belcher J, Farrington K, Davies S.   +5 more
europepmc   +1 more source

Quantifying Weight Loss Prior to Pancreatic Cancer Diagnosis: A Systematic Review and Meta-Analysis. [PDF]

Cancer Med
Price CA, Cooke D, Mold F, Smith NAS, Winn M, Lemanska A.   +5 more
europepmc   +1 more source

Health Status Changes and Long-Term Clinical Outcomes in Patients With Atrial Fibrillation.

JAMA Netw Open
Ohata T, Ikemura N, Kohsaka S, Chan PS, Nakamaru R, Shiraishi Y, Ueda I, Kimura T, Katsumata Y, Nishiyama T, Nakamura I, Ono T, Takatsuki S, Spertus JA, Ieda M.   +14 more
europepmc   +1 more source