Results 181 to 190 of about 3,618,792 (267)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Clinical Characteristics and Diagnostic Pathways of Emphysematous Cystitis in a University Hospital: A Retrospective Observational Study. [PDF]

Adv Urol
Ohno T, Shigemura K, Yanagida K, Kobayashi S, Inoue H, Goto M, Takei K, Minagawa H, Yoshimura I, Kaneko T, Miyake Y, Oba H, Fukagawa T, Kozuma K, Nakagawa T.   +14 more
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Clinical Characteristics and Treatment Outcomes of Pediatric Glaucoma: A Retrospective Cohort Study. [PDF]

J Clin Med
Hanna NN, Canes Napoles D, Flickinger A, Carlos CL, Hertle RW, Gong X.   +5 more
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

OUtcome and Clinical Characteristics of Primary Headache in Patients with Sarcoidosis: The OUCH! Study. [PDF]

Life (Basel)
Tana C, Bernardinello N, Giulianelli G, Moffa S, Cinetto F, Martino L, Buzzelli L, Giamberardino MA, Cipollone F, Martone F, Tana M, Moffa L, Spagnolo P.   +12 more
europepmc   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Clinical characteristics and risk factors of protein-losing enteropathy: a retrospective study. [PDF]

Front Immunol
Tan WT, Wang ZT, Su H, Guo CM, Shen WB, Liu H.   +5 more
europepmc   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Clinical Characteristics and Outcomes of Older Patients Admitted to the Cardiac Intensive Care Unit. [PDF]

JACC Adv
Tarabanis C, Guo J, Barsness GW, Farahmandsadr M, Fordyce CB, Goldfarb M, Katz JN, Kontos MC, Miller PE, Newby LK, van Diepen S, Morrow DA, Alviar CL.   +12 more
europepmc   +1 more source