Results 181 to 190 of about 1,123,091 (301)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

V-PRO Blood Collection Tubes: Validation for Clinical Chemistry and Immunoassay Tests. [PDF]

J Clin Lab Anal
Borai A, Alsharif W, Alhindi A, Alqahtani M, Elsayid M, Khalil H, Al Marwani S, Yagoot A, Magjacot J, Al Meteiri M, Alyamani R, Abdulhakim H, Al-Thaqafy M.   +12 more
europepmc   +1 more source

Total Clinical Chemistry Laboratory Errors and Evaluation of the Analytical Quality Control Using Sigma Metric for Routine Clinical Chemistry Tests. [PDF]

J Multidiscip Healthc, 2021
Teshome M, Worede A, Asmelash D.
europepmc   +1 more source

Clinical Chemistry [PDF]

The American Journal of the Medical Sciences, 1885
openaire   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

No winners or losers: clinical chemistry-based biological aging metrics perform similarly across cohorts and health outcomes. [PDF]

J Gerontol A Biol Sci Med Sci
Provost G, Tanner K, Legault V, Ferrucci L, Bandinelli S, Fried LP, Belsky DW, Laurent B, Cohen AA.   +8 more
europepmc   +1 more source

Frequency of icteric interference in clinical chemistry laboratory tests and causes of severe icterus. [PDF]

Pract Lab Med, 2021
Mainali S, Merrill AE, Krasowski MD.
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Influence of volatile anaesthetics on haematology and clinical chemistry in ferrets. [PDF]

BMC Vet Res
Schröder ML, Reitmeier A.
europepmc   +1 more source