Results 241 to 250 of about 1,123,091 (301)
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
Louis Rosenfeld, Four centuries of clinical chemistry, Amsterdam, Gordon and Breach Science Publishers, 1999, pp. xvii, 562, illus., £91.00 (hardback 90-5699-645-2). [PDF]
, 2002 Lawrence, CJ
core
FEBS Open Bio, EarlyView.KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
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Archives of Internal Medicine, 1975
To the Editor. —The key to Dixon and Laszlo's article "Utilization of Clinical Chemistry Services by Medical House Staff" in theArchives(134:1064-1067, 1974) is their statement that "it remains to be determined by laboratory services whether ultimate cost reductions would warrant the initial costs of instituting selective determinations." At my ...
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To the Editor. —The key to Dixon and Laszlo's article "Utilization of Clinical Chemistry Services by Medical House Staff" in theArchives(134:1064-1067, 1974) is their statement that "it remains to be determined by laboratory services whether ultimate cost reductions would warrant the initial costs of instituting selective determinations." At my ...
openaire +2 more sources
2019
Abstract The aim of this chapter is to help you with your working practical knowledge of clinical chemistry. With so many tests available and increasingly fast laboratory processors, there is a growing temptation to request large numbers of blood tests for every patient.
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Abstract The aim of this chapter is to help you with your working practical knowledge of clinical chemistry. With so many tests available and increasingly fast laboratory processors, there is a growing temptation to request large numbers of blood tests for every patient.
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2014
On being normal in the society of numbersThe essence of laboratory medicineBiochemistry: disease patternsLab results: act nowFluid balance and iv fluid therapyElectrolyte physiology and the kidneyAcid–base balanceHyper- and hyponatraemiaSyndrome of inappropriate adh secretionHyper- and hypokalaemiaCalcium and phosphate physiology...
Murray Longmore +3 more
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On being normal in the society of numbersThe essence of laboratory medicineBiochemistry: disease patternsLab results: act nowFluid balance and iv fluid therapyElectrolyte physiology and the kidneyAcid–base balanceHyper- and hyponatraemiaSyndrome of inappropriate adh secretionHyper- and hypokalaemiaCalcium and phosphate physiology...
Murray Longmore +3 more
openaire +1 more source