Results 291 to 300 of about 599,878 (339)

Ultrasound‐Triggered Release of Anticancer Nanoparticles from Electrospun Fabrics Integrated with Soft Robotic Tentacles

open access: yesAdvanced NanoBiomed Research, EarlyView.
Early pancreatic cancer detection remains challenging, causing poor treatment outcomes. This article introduces an innovative, ultrasound (US)‐triggered localized drug delivery system using gelatin nanoparticles embedded in electrospun fabric and integrated with magnetic tentacle robotics.
Samuel C. T. Moorcroft   +6 more
wiley   +1 more source

Decoding a Gut Commensal Signal: Structural and Immunological Profiling of Segatella Copri Lipopolysaccharide

open access: yesAngewandte Chemie, EarlyView.
The lipopolysaccharide (LPS) of Segatella copri is a structurally unique, immunomodulatory glycoconjugate. Combining mass spectrometry (MS), nuclear magnetic resonance (NMR), and cytometry by time‐of‐flight (CyTOF), we uncover a rough‐type LPS with reduced TLR4 agonism and selective monocyte effects, further highlighting the key role of LPS chemistry ...
Luca De Simone Carone   +17 more
wiley   +1 more source

Synthesis and Application of Bioactive N‐Functionalized Aziridines

open access: yesAngewandte Chemie, EarlyView.
This review discusses modern synthetic methods for the preparation of aziridine‐containing small molecules, including biocatalytic, electrocatalytic, and photocatalytic strategies. We highlight the compatibility of various synthetic methods with control of the exocyclic N‐substituent.
Hao Tan   +4 more
wiley   +1 more source

Conformational Quenching in an Engineered Lipocalin Protein Achieves High Affinity Binding to the Toxin Colchicine

open access: yesAngewandte Chemie, EarlyView.
Specific high affinity recognition of colchicine by an engineered anticalin involves loop dynamics and conformational selection Abstract The engineered lipocalin Colchicalin binds the clinically relevant plant toxin colchicine with picomolar affinity.
Mark J. Bostock   +6 more
wiley   +1 more source

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