Results 81 to 90 of about 2,967,291 (296)

Vitiligo-like lesions located over In-transit metastases of malignant melanoma as a clinical marker of complete response to pembrolizumab. [PDF]

, 2019
Anti-programmed cell death (PD)-1 therapies in metastatic tumors have a high incidence of immune adverse events, including cutaneous manifestations such as vitiligo-like lesions. This side effect is associated with increased survival and it is a clinical
Gracia-Cazaña, Tamara, Hernández-García, Alba, Padgett, Esteban, Sánchez-Salas, María Pilar   +3 more
core  

The prognostic and predictive power of redox rotein expression for anthracycline-based chemotherapy response in locally advanced breast cancer [PDF]

, 2012
Neoadjuvant chemotherapy has become the standard of care for locally advanced primary breast cancer. Anthracycline-based regimens have proven to be one of the most effective treatments in this setting.
A Ravid, AE Ring, AF Howie, Ahmad Al-Attar, B Chevallier, BK Arun, C Cadenas, Caroline M Woolston, CM Woolston, CM Woolston, D Mayr, D Ravi, D Shin, E Junn, HM Kuerer, I Muller, Ian O Ellis, J Huang, JA Mobley, JA Moscow, JD Pennington, JH Jeon, JO Park, L Behrend, L Gilbert, L Moureau-Zabotto, LC Alpert, Lei Zhang, LM Butler, LM Forrester, LM Mcshane, M Valko, MM Montano, Mohamed Shehata, S Toyokuni, Sarah J Storr, SH Han, SM Mense, Stephen Y Chan, Stewart G Martin, Y Nakanishi   +40 more
core   +2 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Deep learning analysis of MRI to assess rectal cancer treatment

Frontiers in Oncology
IntroductionTraditional neoadjuvant therapy for locally advanced rectal cancer (LARC) results in pathologic complete response (pCR) in approximately 15% of patients, supporting non-operative strategies for those with clinical complete response (cCR). The
Heather M. Selby, Ashley Y. Son, Vipul R. Sheth, Todd H. Wagner, Todd H. Wagner, Erqi L. Pollom, Arden M. Morris   +6 more
doaj   +1 more source

Montelukast in the treatment of duodenal eosinophilia in children with dyspepsia: Effect on eosinophil density and activation in relation to pharmacokinetics [PDF]

, 2009
Background We have previously demonstrated the clinical efficacy of montelukast in a randomized double-blind controlled cross-over trial in patients with dyspepsia in association with duodenal eosinophilia.
Taylor Debra L, Schurman Jennifer V, Neilan Nancy A, Friesen Craig A, Kearns Gregory L, Abdel-Rahman Susan M   +5 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Watch-and-Wait strategy for locally advanced rectal cancer after neoadjuvant chemoradiotherapy: a comprehensive review

Frontiers in Oncology
The conventional treatment for locally advanced rectal cancer (LARC) primarily involves neoadjuvant chemoradiotherapy (nCRT) combined with total mesorectal excision (TME).
Peng Huang, Xiaoyue Zhao, Huanhuan Fei, Linzhu Zhang, Xiaofan Liu, Yongjun Yu, Rong Wu, Fei Fei   +7 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Case report: Watch-and-wait strategy in resectable esophageal cancer following neoadjuvant chemoimmunotherapy: a case series

Frontiers in Immunology
Neoadjuvant chemoimmunotherapy (NCIT) has improved pathological complete response and conferred survival benefits in patients with locally advanced esophageal cancer. However, surgical complications unrelated to the tumor continue to detract from patient
Lingyu Tan, Lingyu Tan, Guozhen Yang, Guozhen Yang, Chufeng Zeng, Chufeng Zeng, Xu Zhang, Xu Zhang, Xu Zhang   +8 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source