Results 81 to 90 of about 13,627,543 (246)

The comparison of clinical and histopathologic findings according to the complete response to treatment.

, 2021
The comparison of clinical and histopathologic findings according to the complete response to treatment.
Elvina Almuradova (11663234), Merve Guner Oytun (11663231), Mustafa Harman (11663237), Ruchan Uslu (816262), Gulcan Bulut (11663228), Bulent Karabulut (11663240)   +5 more
core   +1 more source

Safety and Efficacy of a Sandwich Total Neoadjuvant Therapy Strategy for Low‐Risk Distal Locally Advanced Rectal Cancer: Results From the TESS Phase II Trial

MedComm
This prospective phase II multicenter study evaluated a novel sandwich total neoadjuvant treatment (TNT) strategy for patients with relatively low‐risk distal locally advanced rectal cancer (LARC).
Shuang Liu, GuangZhao Lv, GeYu Xu, XiaoZhong Wang, YeZhong Zhuang, ShouMin Bai, HaiNa Yu, XiaoJun Wu, YiJing Ye, HuiLong Luo, ShuoYu Xu, QiaoXuan Wang, Hui Chang, PeiQiang Cai, ZhiZhong Pan, YuanHong Gao, Gong Chen, WeiWei Xiao   +17 more
doaj   +1 more source

Hyperbaric oxygen therapy as an immunosensitizing strategy in advanced gastric hepatoid adenocarcinoma: a case report

Frontiers in Immunology
BackgroundHepatoid adenocarcinoma of the stomach (HAS) is a rare but highly aggressive subtype of gastric cancer (GC) associated with an unfavorable prognosis, particularly in advanced or metastatic stages.
Wenke Li, Jing Wei, Pengfei Zhang, Mo Cheng, Menghui Xu, Lin Zhu, Ming Liu   +6 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Total Neoadjuvant Therapy Versus Long-Course Chemoradiotherapy in Locally Advanced Rectal Cancer: Real-World Tumor Response and Clinical Outcomes

Medical Sciences
Background: Total neoadjuvant therapy is becoming a preferred option for locally advanced rectal cancer, particularly in patients with high-risk baseline features.
Sorinel Lunca, Wee Liam Ong, Stefan Morarasu, Ana Maria Musina, Cristian Ene Roata, Raluca Zaharia, Gabriel Mihail Dimofte   +6 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Organ preservation after neoadjuvant immunotherapy in mismatch repair-deficient colorectal cancer: response assessment, watch-and-wait, and salvage surgery

Frontiers in Oncology
Neoadjuvant immune checkpoint blockade has produced high pathological and clinical response rates in mismatch repair-deficient (dMMR) or microsatellite instability-high (MSI-H) colorectal cancer, raising the possibility of response-adapted organ ...
Nan Yao, Guoshuai Xu, Ning Duan, Fuzhou Han, Wenqiang Li, Jun Qu   +5 more
doaj   +1 more source