Results 251 to 260 of about 1,803,951 (318)

Development of a clinical decision support system for breast cancer detection using ensemble deep learning. [PDF]

Sci Rep
Sandhu JK, Sharma C, Kaur A, Pandey SK, Sinha A, Shreyas J.   +5 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Evaluation of an AI-Based Clinical Decision Support System for Perioperative Care of Older Patients: Ethical Analysis of Focus Groups With Older Adults. [PDF]

JMIR Aging
Parchmann N, Orzechowski M, Brefka S, Steger F.   +3 more
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Clinical decision support system impact on diagnostic imaging appropriateness and value-driven outcomes in a Singapore emergency department: Protocol of a pragmatic controlled before-after study. [PDF]

PLoS One
Tay YX, Foley SJ, Killeen R, Wee JCP, Chua ISY, Ong MEH, Doran P, Chen RC, Chan LP, Mak MS, McNulty JP.   +10 more
europepmc   +1 more source

Effectiveness of Using Clinical Decision Support System in Nursing Records

Chin-Yuan Tsan, Ching-Mei Tsai, Yi-Chen Wang   +2 more
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Reusable Generic Clinical Decision Support System Module for Immunization Recommendations in Resource-Constraint Settings. [PDF]

AMIA Jt Summits Transl Sci Proc
Orlioglu S, Boobalan AS, Abanyie K, Boyce RD, Min H, Gong Y, Sittig DF, Biondich P, Wright A, Nøhr C, Law T, Robinson D, Faxvaag A, Hubig N, Gimbel R, Rennert L, Jing X.   +16 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source