Results 161 to 170 of about 685,546 (303)

The Value of Clinical Judgment in the Detection of Clinical Deterioration [PDF]

JAMA Internal Medicine, 2015
Amitkumar R, Patel, Frank J, Zadravecz, Robert S, Young, Mark V, Williams, Matthew M, Churpek, Dana P, Edelson   +5 more
openaire   +2 more sources

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Treatment Recommendations for Clinical Deterioration on the Wards: Development and Validation of Machine Learning Models. [PDF]

JMIR AI
Pulick E, Carey KA, Qyli T, Oguss MK, Picart JK, Penumalee L, Nezirova LK, Tully ST, Gilbert ER, Shah NS, Ravichandran U, Afshar M, Edelson DP, Mintz Y, Churpek MM.   +14 more
europepmc   +1 more source

An assessment of failure to rescue derived from routine NHS data as a nursing sensitive patient safety indicator (report to Policy Research Programme)

, 2010
Objectives: This study aims to assess the potential for deriving 2 mortality based failure to rescue indicators and a proxy measure, based on exceptionally long length of stay, from English hospital administrative data by exploring change in coding ...
Bottle, Alex, Griffiths, Peter, Jones, Simon   +2 more
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Contrast Reflux Into IVC in Acute Pulmonary Embolism Predicts Clinical Deterioration Risk. [PDF]

Pulm Circ
Leverone NA, Singer AG, Lopez AA, Ellberg C, Henry PJ, Kabadi AA, Self AA, Leverone DM, Yen A, Hahn L, Karunamuni J, Weihe E, Yang JZ, McGuire WC, Papamatheakis DG, Morris TA, Fernandes TM.   +16 more
europepmc   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Intracranial haemorrhage without early clinical deterioration after mechanical thrombectomy: rethinking the "asymptomatic" label. [PDF]

Eur Stroke J
Riegler C, Nolte CH, von Rennenberg R, Bollweg K, Hahn M, Uphaus T, Alegiani A, Illies T, Wischmann J, Kellert L, Bernkopf K, Wunderlich S, Hennersdorf F, Poli S, Mann L, Keil F, Jamous A, Ernst MS, Bürkle F, Wiesmann M, Akkurt B, Faizy T, Audebert HJ, Wattjes MP, Siebert E, Nawabi J.   +25 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Assessing Clinical Deterioration in Children With Dark-Coloured Skin: A Scoping Review. [PDF]

J Clin Nurs
Kelly C, Leslie GD, Laird P, Stokes S, Gill FJ.   +4 more
europepmc   +1 more source