Results 131 to 140 of about 8,630,835 (311)

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Clinical efficacy and safety of statins in managing cardiovascular risk

open access: yes, 2008
Navin K Kapur1, Kiran Musunuru21Division of Cardiology, Tufts University – New England Medical Center; Boston, MA, USA; 2Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USAAbstract: Since their introduction in ...
Navin K Kapur, Kiran Musunuru
core  

The effects of early clinical teaching experiences on pre-service teachers' self-efficacy [PDF]

open access: yes, 2011
In-service teachers are often lack sufficient teaching experience (Block et al, 2010) which leads to being psychologically unprepared to confront many challenges in teaching.
Androzzi, Jared   +1 more
core  

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

Current Therapeutic Progress of CDK4/6 Inhibitors in Breast Cancer

open access: yesCancer Management and Research, 2020
Yanmei Wu,1 Yu Zhang,2 Hao Pi,1 Yuan Sheng1 1Department of Breast and Thyroid Surgery, Changhai Hospital, Navy Medical University, Shanghai 200433, People’s Republic of China; 2Medical Affairs, Pfizer Biopharmaceutical Group, Shanghai 200041 ...
Wu Y, Zhang Y, Pi H, Sheng Y
doaj  

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

open access: yesMolecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen   +19 more
wiley   +1 more source

Comparision between therapeutic efficacy of terbinafine and ketoconazole in Tinea versicolor [PDF]

open access: yes
Background and Objective: Tinea versicolor is a common fungal infection of the skin caused by the dimorphic lipophilic yeast Pityrosporum orbicular (Malassezia furfur). Lesions begin as multiple small, circular macules of various colors.
نسیمی , مریم   +2 more
core  

The Study of the clinical teaching to increase the self-efficacy of nursing Students : From the analysis of the clinical practice experience of the students with low self-efficacy [PDF]

open access: yes, 2002
The purpose of this study was to analyze the clinical practice experiences of 8 nursing students with low self-efficacy before and after their practice, and to discuss the effective way of teaching the students.
阪口, しげ子   +2 more
core  

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

open access: yesMolecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira   +7 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

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