Results 181 to 190 of about 495,016 (275)

Obstetric characteristics and maternal outcomes of early second‐trimester placenta accreta spectrum

open access: yesInternational Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To describe early second‐trimester placenta accreta spectrum (PAS) management and outcomes. Methods This cross‐sectional study queried the US Healthcare Cost and Utilization Project's National Inpatient Sample from 2016 to 2021, finding 905 cases with a diagnosis of PAS between 14 and 22 weeks of gestation and in‐hospital management.
Mihiri S. Karunaratne   +8 more
wiley   +1 more source

Maternal diabetes mellitus during pregnancy as a risk factor for strabismus and refractive errors in the offspring—A large‐scale national study

open access: yesInternational Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To investigate whether maternal diabetes during pregnancy is associated with increased risk of strabismus and refractive errors (RE) in their offspring. Methods This retrospective cohort study utilized electronic medical records from Clalit Health Services (CHS) in Israel, 2001–2023. Births were categorized by maternal diabetes type (
Nir Amitai   +8 more
wiley   +1 more source

Cancer and fertility management: FIGO best practice advice

open access: yesInternational Journal of Gynecology &Obstetrics, EarlyView.
Abstract Cancer diagnoses in patients of reproductive age require balancing urgent oncological treatment with the need to preserve fertility. This FIGO Best Practice Advice outlines key considerations for fertility management in this population given the rising cancer incidence among young women and the reproductive risks posed by cancer treatments ...
Nikhil Purandare   +28 more
wiley   +1 more source

Metformin Administration Protects Against Deltoid Tendon Damage Through Activation of Notch Signaling

open access: yesiMeta, EarlyView.
Type 2 Diabetes Mellitus (T2DM) is a growing global health concern that is associated with severe complications including diabetic tendinopathy. In this study, we found that T2DM patients had a significantly higher prevalence of tendon surgery compared to non‐T2DM patients, which were alongside impaired ECM and cell adhesion. Notably, metformin‐treated
Can Liu   +16 more
wiley   +1 more source

The Utility of Fourier Transform Infrared Spectroscopy (FTIR) for Detecting Exercise‐Induced Changes in the Human Hand Epidermis

open access: yesJournal of Biophotonics, EarlyView.
This study demonstrates that physical exercise induces measurable biochemical changes in the epidermis. FTIR spectroscopy detected significant post‐exercise increases in spectral peaks related to lipids, phospholipids, and carbohydrates, highlighting the method's potential for non‐invasive skin and metabolism monitoring in athletes.
Paweł Król   +8 more
wiley   +1 more source

Intranasal Naloxone During Recurrent Exercise in Individuals with Type‐1 Diabetes Mellitus: Evaluation of the Clinical Predictors of Pharmacokinetics and Exposure–Response

open access: yesThe Journal of Clinical Pharmacology, EarlyView.
Abstract Impaired awareness of hypoglycemia (IAH) impacts 25%–30% of individuals with type 1 diabetes mellitus (T1D), potentially leading to severe outcomes due to reduced symptom perception. Naloxone, a mu‐opioid receptor antagonist, shows promise as a preventive measure against IAH.
Omar N. Al Yacoub   +9 more
wiley   +1 more source

Utilization of Proteomic Measures for Early Detection of Drug Benefits and Adverse Effects

open access: yesThe Journal of Clinical Pharmacology, EarlyView.
Abstract Recognition of benefits and adverse effects of therapies in earlier clinical trial phases could improve the safety, efficiency, and cost of clinical trials. Using four clinical trials representing a diverse set of diseases and drug classes (EXSCEL: exenatide/GLP‐1 RA, SUGAR‐DM‐HF: empagliflozin/SGLT2i, PRADA: epirubicin/anthracycline, and ...
Jessica Chadwick   +17 more
wiley   +1 more source

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