Results 61 to 70 of about 518,253 (265)

Phenotypic Assessment of Exoenzyme Activity by Clinical Isolates of Staphylococcus aureus

RADS Journal of Biological Research & Applied Science, 2015
Staphylococcus aureus is a common causative agent of hospital infection and community acquired infection as the cell possesses a wide armamentarium of virulence factor that include different exoenzyme and toxins.
Yusra Siddiqui
doaj  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Seroprevalence of IgG anti-Toxocara species antibodies in a population of patients with suspected allergy

International Journal of General Medicine, 2011
Rosanna Qualizza1, Cristoforo Incorvaia2, Romualdo Grande3, Eleni Makri2, Luigi Allegra31Allergy Service, 2Allergy/Pulmonary Rehabilitation, Istituti Clinici di Perfezionamento, 3IRCCS Fondazione Cà Granda, Milan, ItalyBackground: Toxocara ...
Qualizza R, Incorvaia C, Grande R, Makri E, Allegra L   +4 more
doaj  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Evaluation of Some Liver Function Tests in Clinical Cases of Hepatic Insufficiency in Buffaloes

Italian Journal of Animal Science, 2010
The investigation was conducted on 35 clinical cases of hepatic insufficiency in buffaloes. The cases for study were selected on the basis of clinical symptoms and results of liver function tests. All these cases were anorectic and non-febrile.
S. Sridhar, V. Sharma
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Radical-mediated Electrical Enzyme Assay For At-home Clinical Test

To meet the growing demand for accurate, rapid, and cost-effective at-home clinical testing, we developed a radical-mediated enzyme assay (REEA) integrated with a paper fluidic system and electrically read by a handheld field-effect transistor (FET) device. The REEA utilizes horseradish peroxidase (HRP) to catalyze the conversion of aromatic substrates
Jang, Hyun-June, Joung, Hyou-Arm, Shi, Xiaoao, Ding, Rui, Wagner, Justine, Tang, Erting, Zhuang, Wen, Ryu, Byunghoon, Chen, Guanmin, Yeo, Kiang-Teck Jerry, Huang, Jun, Chen, Junhong   +11 more
openaire   +2 more sources

Demand management and optimization of clinical laboratory services in a tertiary referral center in Saudi Arabia

Annals of Saudi Medicine, 2018
BACKGROUND: Demand for clinical laboratory services in our institution has increased by 7% each year in the past 5 years, while the amount budgeted for services has remained fixed.
Thomas F. Morris, Tracy Louise Ellison, Maysoon Mutabagani, Sahar Isa Althawadi, Martin Heppenheimer   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Modern Approach to Fabry Disease Diagnosis and Management in Children

Вопросы современной педиатрии
Fabry disease (FD), or Andersen-Fabry disease, is a rare hereditary lysosomal disease (sphingolipids storage disease) characterized by progressive multisystem involvement.
Olga Ya. Smirnova, Nato D. Vashakmadze, Maria S. Karaseva, Natalia V. Zhurkova, Anna Yu. Rachkova, Leyla S. Namazova-Baranova   +5 more
doaj   +1 more source