Results 41 to 50 of about 3,257,610 (298)

Experience of Using Therapeutic Drug Monitoring to Control the Safety of Vancomycin in Intensive Care Unit Patients with Sepsis

Безопасность и риск фармакотерапии, 2022
Vancomycin is prescribed to patients in serious condition with infections caused by Gram-positive microorganisms; however, if the therapeutic plasma concentration of the medicinal product is exceeded, it can have a nephrotoxic effect.The aim of the study
A. B. Prokofiev, S. A. Belkov, R. E. Kazakov, N. G. Berdnikova, T. A. Rodina, E. S. Melnikov, A. A. Danko, N. E. Voronova, R. Z. Vafina, A. V. Zavtoniev, D. V. Tsyganko, E. Yu. Demchenkova   +11 more
doaj   +1 more source

Assessment of outcome in clinical trials in mild Alzheimer 19s disease: urgent time for a rethink? [PDF]

, 2013
Introduction: A major barrier for clinical trials in Alzheimer's disease is the lack of sensitive clinical endpoints for the early stages. Until recently, regulatory agencies have required demonstration of improvement in two disease domains, cognition ...
McGoldrick, S., Duffy, Fiona, McGoldrick, Susan, Reynish, Emma, Kelly, Fiona, Morrison, Y., Wilson, L., Bennett, Crispin, Wilson, J T Lindsay, Bennett, C., Morrison, Yvonne, Duffy, F., Reynish, E.   +12 more
core  

Introducing service improvement to the initial training of clinical staff [PDF]

, 2010
It is well recognised in healthcare settings that clinical staff have a major influence over change in how services are provided. If a culture of systematic service improvement is to be established it is essential that clinical staff have an ...
Lister, Sue, Johnson, N., Robinson, Dilys, Cooke, M, Janes, G, Cooke, Matthew (Professor of clinical systems design), Penny, J., Penny, Jean, Robinson, D, Johnson, N, Janes, G., Cooke, Matthew W, Dilys, Robinson, Fowler-davis, S., Cooke, M. W., Lister, S., Janes, Gillian, Lister, S, Cooke, Matthew W., Penny, J, Dilys, R., Fowler-Davis, Sally, Johnson, Neil, Johnson, N. (Neil)   +23 more
core   +1 more source

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source

Difficulties encountered in testing, scoring, and interpreting balance performance in older adults using clinical evaluation tools: a cross-sectional study

MGM Journal of Medical Sciences, 2023
Background: Balance impairment is one of the primary intrinsic risk factors contributing to falls in older adults. Prior research has consolidated the prevalent clinical tools for detecting balance issues in this demographic.
Poonam A Desai, Rajani Mullerpatan
doaj   +1 more source

Clinical Evaluation of Rodents

Veterinary Clinics of North America: Exotic Animal Practice, 1999
The clinical examination of small rodents is like that of more conventional pets in that the same systematic approach is used to arrive at a problem list. The difference with these species is that their diminutive size, high metabolic rate, and lack of patience may be problematic for the clinician.
openaire   +2 more sources

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Clinical radiology: Going an extra mile for patient care

Indian Journal of Radiology and Imaging, 2018
Context: Clinical details help radiologists report accurately. However, the clinical aspect has taken a backseat among radiologists, who are overdependent on referral notes.
Upendra Kumar Joish, Hirdesh Sahni, R Harikiran Reddy, Vivek Sreekanth   +3 more
doaj   +1 more source

PIMP Your Stride: Preferred Running Form to Guide Individualized Injury Rehabilitation

Frontiers in Rehabilitation Sciences, 2022
Despite the wealth of research on injury prevention and biomechanical risk factors for running related injuries, their incidence remains high. It was suggested that injury prevention and reconditioning strategies should consider spontaneous running forms
Cyrille Gindre, Bastiaan Breine, Bastiaan Breine, Aurélien Patoz, Aurélien Patoz, Kim Hébert-Losier, Kim Hébert-Losier, Adrien Thouvenot, Adrien Thouvenot, Laurent Mourot, Laurent Mourot, Thibault Lussiana, Thibault Lussiana   +12 more
doaj   +1 more source

International integrated database for the evaluation of severe sepsis (INDEPTH): clinical evaluation committee report on the safety of drotrecogin alfa (activated) therapy.

, 2008
OBJECTIVE: INDEPTH is an integrated database of five trials enrolling patients with severe sepsis. It was created to better understand safety of drotrecogin alfa (activated) (DrotAA) in severe sepsis, examine factors impacting management of sepsis ...
INDEPTH Clinical Evaluation Committee, Dhainaut, Jean-François, Laterre, Pierre-François   +2 more
core   +1 more source