Results 211 to 220 of about 571,832 (268)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Can the co-localization of CD8+, PD-1, PD-L1 AND PD-L2 patterns provide guidance in clinical outcomes of patients with head and neck cutaneous squamous cell carcinoma? [PDF]

Braz J Otorhinolaryngol
Bento GN, de Oliveira Santos AB, Matos LL, Faquin WC, Pai SI, Cernea CR.   +5 more
europepmc   +1 more source

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The Clinical Evolution of Lyme Arthritis

Annals of Internal Medicine, 1987
To determine the clinical evolution of Lyme arthritis, 55 patients who did not receive antibiotic therapy for erythema chronicum migrans were followed longitudinally for a mean duration of 6 years. Of the 55 patients, 11 (20%) had no subsequent manifestations of Lyme disease.
A C, Steere, R T, Schoen, E, Taylor
openaire   +2 more sources

Evolution of a Geriatric Evaluation Clinic

Journal of the American Geriatrics Society, 1984
Multidisciplinary geriatric evaluation units are being established in hospitals and, to a lesser extent, as outpatient clinics. This paper presents results of a chart audit of 332 patients seen from 1978 to 1982 at a university based geriatric outpatient evaluation unit.
J T, Moore, G A, Warshaw, L D, Walden, K, Rask, N E, Clapp-Channing   +4 more
openaire   +2 more sources

Evolution of the Clinically Negative Neck

Annals of Otology, Rhinology & Laryngology, 1980
A retrospective study was done of 602 patients with primary squamous cell carcinoma of the upper aerodigestive tract and a clinically negative neck (N o ) seen at the University of Illinois Hospital between 1960–1975. There was no uniform policy as to the treatment of N o
E M, Skolnik, A H, Katz, S P, Becker, R, Mantravadi, S, Stal   +4 more
openaire   +2 more sources

The Evolution of Clinical Policies

Medical Care, 1990
Physicians use clinical policies as guidelines in the day-to-day management of patients. Some policies, by reducing otherwise complicated dilemmas to simple rules, encourage improved patient outcomes, but some are adopted without any evidence of benefit; some may be extended beyond their proper limitations and others are used despite accumulating data ...
openaire   +2 more sources

The clinical evolution of the 'Dahl Principle'

British Dental Journal, 1997
The restorative management of patients with localised tooth wear is a major challenge to the dental profession. There is rarely adequate interocclusal space available to place restorations without the need for extensive tooth preparation or the involvement of many unaffected teeth.
P F, Briggs, K, Bishop, S, Djemal
openaire   +2 more sources

A Clinical Study of Migraine Evolution

Headache: The Journal of Head and Face Pain, 2006
Background.—The buildup time of migraine headaches has not been well delineated in publications to date and we are aware of patients whose migraines last well over 72 hours. More concentration on these factors in the assessment of patients might lead to more appropriate therapeutic choices.
William, Pryse-Phillips, Michel, Aubé, Peter, Bailey, Werner J, Becker, Andre, Bellavance, Marek, Gawel, Rose, Giammarco, Gordon, Mackie, R Allan, Purdy, Gordon, Robinson, Gary, Shapero, Keith, Wilson   +11 more
openaire   +2 more sources