Results 61 to 70 of about 21,937,235 (349)

Assessing the similarity of dose response and target doses in two non-overlapping subgroups [PDF]

, 2017
We consider two problems that are attracting increasing attention in clinical dose finding studies. First, we assess the similarity of two non-linear regression models for two non-overlapping subgroups of patients over a restricted covariate space.
Bretz, Frank, Dette, Holger, Liu, Wei, Möllenhoff, Kathrin, Trampisch, Matthias   +4 more
core   +2 more sources

Genome-wide mRNA profiling in urinary extracellular vesicles reveals stress gene signature for diabetic kidney disease

iScience, 2023
Summary: Urinary extracellular vesicles (uEV) are a largely unexplored source of kidney-derived mRNAs with potential to serve as a liquid kidney biopsy.
Om Prakash Dwivedi, Karina Barreiro, Annemari Käräjämäki, Erkka Valo, Anil K. Giri, Rashmi B. Prasad, Rishi Das Roy, Lena M. Thorn, Antti Rannikko, Harry Holthöfer, Kim M. Gooding, Steven Sourbron, Denis Delic, Maria F. Gomez, Per-Henrik Groop, Tiinamaija Tuomi, Carol Forsblom, Leif Groop, Maija Puhka   +18 more
doaj   +1 more source

Aligning the top-level of SNOMED-CT with Basic Formal Ontology [PDF]

, 2008
Effective translational research requires automated analysis of large datasets collected by multiple researchers working at multiple locations. Reliable, machine interpretation of-—and reasoning with—-large datasets assembled at different ...
William Hogan
core   +2 more sources

A PRSZT Registry Analysis of Prognostic Factors Influencing Survival and Relapse Rates After Second Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT A second allogeneic (allo‐)hematopoietic stem cell transplantation (HSCT2) is a potential curative option for pediatric patients with acute lymphoblastic leukemia (ALL) following relapse after first allogeneic transplantation (HSCT1), but its efficacy is limited by high relapse rates and transplant‐related toxicity in highly pretreated ...
Ava Momm, Imme Haubitz, Rita Beier, Martin Zimmermann, Andrej Lissat, Peter Bader, Matthias Eyrich, Jan‐Henning Klusmann, Matthias Wölfl, Paul‐Gerhardt Schlegel, Verena Wiegering   +10 more
wiley   +1 more source

Correlation between Joint Erosion and Clinical and Laboratory Findings in Rheumatoid Arthritis

پزشکی بالینی ابن سینا, 2009
Introduction & Objective: Rheumatoid Arthritis (RA) is a chronic progressive inflammatory disease of the articular joint that results in significant pain, stiffness and swelling and leads to destruction.
Zahra Basiri, Mandana Biranvand, Ebrahim Nadi, Mahmood Gholyaf, Mohammad Samet   +4 more
doaj  

Integrated miRNA/cytokine/chemokine profiling reveals severity-associated step changes and principal correlates of fatality in COVID-19

iScience, 2022
Summary: Inflammatory cytokines and chemokines (CC) drive COVID-19 pathology. Yet, patients with similar circulating CC levels present with different disease severity. Here, we determined 171 microRNAomes from 58 hospitalized COVID-19 patients (Cohort 1)
Julie C. Wilson, David Kealy, Sally R. James, Tobias Plowman, Katherine Newling, Christopher Jagger, Kara Filbey, Elizabeth R. Mann, Joanne E. Konkel, Madhvi Menon, Sean B. Knight, Angela Simpson, Aliya Prihartadi, Greg Forshaw, Neil Todd, David R.A. Yates, John R. Grainger, Tracy Hussell, Paul M. Kaye, Nathalie Signoret, Dimitris Lagos   +20 more
doaj   +1 more source

Ataxia with oculomotor apraxia type 2: a clinical, pathologic, and genetic study [PDF]

, 2006
BACKGROUND: Ataxia with oculomotor apraxia type 2 (AOA2) is characterized by onset between age 10 and 22 years, cerebellar atrophy, peripheral neuropathy, oculomotor apraxia (OMA), and elevated serum alpha-fetoprotein (AFP) levels. Recessive mutations in
BANFI S, BARBIERI, FABRIZIO, CASALI C., CHESSA L, CRISCUOLO C, DE MICHELE, GIUSEPPE, DI GIANDOMENICO S, FILLA, ALESSANDRO, GALLOSTI L, GRIECO GS, MANCINI P, PIANE M, PIERELLI F, RIZZUTO N, SACCA', FRANCESCO, SANTORELLI FM   +15 more
core  

Word-finding difficulty: a clinical analysis of the progressive aphasias.

Brain : a journal of neurology, 2007
The patient with word-finding difficulty presents a common and challenging clinical problem. The complaint of 'word-finding difficulty' covers a wide range of clinical phenomena and may signify any of a number of distinct pathophysiological processes ...
J. Rohrer, W. Knight, J. Warren, Nick C Fox, M. Rossor, J. Warren   +5 more
semanticscholar   +1 more source

Evaluation of the Utility of Baseline Echocardiogram in Patients With Standard Risk Precursor B‐Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
Abstract Background A routine baseline echocardiogram is often obtained prior to anthracycline administration in children with cancer. The utility of baseline echocardiogram is unclear in patients with standard risk B‐cell acute lymphoblastic leukemia (SR B‐ALL) as their anthracycline cumulative dose is low.
Ziyad Alrajhi, Alice Pozza, Luc Mertens, Adam Paul Yan, Sarah Alexander   +4 more
wiley   +1 more source

Clinical presentation, diagnostic findings and outcome of dogs with presumptive spinal-only meningoencephalomyelitis of unknown origin [PDF]

, 2017
Objectives: To summarise clinical presentation, diagnostic findings and long-term outcome for dogs clinically diagnosed with meningoencephalomyelitis of unknown origin affecting the spinal cord alone.
Cardy, Coates, Csebi, Da Costa, De Risio, Dewey, Eminaga, Fenn, Granger, Griffin, Meric, Parry, Scott, Tipold   +13 more
core   +2 more sources