Results 161 to 170 of about 4,346,835 (341)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

The Clinical History and Basic Science Origins of Transcutaneous Osseointegration for Amputees. [PDF]

Adv Orthop, 2022
Hoellwarth JS, Tetsworth K, Akhtar MA, Al Muderis M.   +3 more
europepmc   +1 more source

[Arthritis and clinical history].

Acta medica portuguesa, 2012
In front of a patient with arthritis, clinical good-sense tells that the most probable diagnosis are the most prevalent ones. Nevertheless, we have to exclude a multiplicity of other aetiologies, less frequent, but with highest implications in the therapeutic conduct.
Lígia, Silva, Luzia, Sampaio, José, Pinto, Francisco S, Ventura   +3 more
openaire   +1 more source

Prevalence, clinical aspects, and natural history of IgM MGUS

, 2010
Mary L. McMaster, Ola Landgren
openalex   +2 more sources

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Progressive telomere shortening is part of the natural history of chronic lymphocytic leukaemia and impacts clinical outcome: evidences from long term follow‐up [PDF]

, 2017
Paola Ghione, Elisa Genuardi, Davide Rossi, Daniela Drandi, Barbara Mantoan, Daniela Barbero, Elisa Bernocco, Luigia Monitillo, Michaela Cerri, Marina Ruggeri, Paola Omedè, Clara Deambrogi, Lorenzo De Paoli, Roberto Passera, Marta Coscia, Federica Cavallo, Massimo Massaia, Mario Boccadoro, Gianluca Gaïdano, Marco Ladetto, Simone Ferrero   +20 more
openalex   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Role of clinical history in beta-lactam hypersensitivity. [PDF]

Curr Opin Allergy Clin Immunol, 2021
Plager J, Judd A, Blumenthal K.
europepmc   +1 more source

Clinical History [PDF]

, 2020
openaire   +1 more source

Adults With Oral High-risk Human Papillomavirus (HPV) and/or Smoking History Have a Higher Risk for Clinically Diagnosed Oral Premalignant Lesions

, 2015
Susan G. Reed, Amy E. Wahlquist
openalex   +1 more source