Results 191 to 200 of about 4,346,835 (341)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Retracted: Growth Differentiation Factor-15 Based ABC (Age, Biomarkers, Clinical History)-AF (Atrial Fibrillation)-Bleeding Risk Score for Elderly Patients with Nonvalvular Atrial Fibrillation. [PDF]

J Healthc Eng, 2023
Healthcare Engineering JO.
europepmc   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Hierarchical machine learning model integrating clinical history and nursing observations for predicting violent behavior in hospitalized schizophrenia patients. [PDF]

Front Psychiatry
Meng X, Wang L, Duan Y, Zhu G, Wang J, Sun Y, Wang M, Liu M, Sun C, Pang L, Hu K, Yang W, Shao W, Ren J, Shao X, Zhang Y.   +15 more
europepmc   +1 more source

An online case-based teaching and assessment program on clinical history-taking skills and reasoning using simulated patients in response to the COVID-19 pandemic. [PDF]

BMC Med Educ, 2023
Duffy B, Tully R, Stanton AV.
europepmc   +1 more source

Clinical and medical history aspects of gastroesophageal reflux disease with regard to the patient’s dental status

, 2015
Yu. I. Bondarenko, V. Ya. Lobanets, I. Yo. Niverovskyi, V. I. Chernetskyi   +3 more
openalex   +2 more sources

Bias in the Reporting of Family History: Implications for Clinical Care [PDF]

, 2012
Elissa M. Ozanne, Adrienne O'Connell, Colleen Bouzan, Phil Bosinoff, Taryn Rourke, Dana Dowd, Brian Drohan, Fred Millham, Patrick R. Griffin, Elkan F. Halpern, Alan Semine, Kevin S. Hughes   +11 more
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Evaluation of Providers' Assessment of Clinical History When Using the HEART Score in the Emergency Department in the Kingdom of Saudi Arabia Hospitals: A Cross-Sectional Study. [PDF]

Cureus
Hawati SM, Binobaid F, Alsaeigh A, Alameer W, Almontashri RM, Qari A, Maghrabi G.   +6 more
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source