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Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

open access: yesFEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima   +4 more
wiley   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

open access: yesFEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli   +9 more
wiley   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

open access: yesFEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig   +7 more
wiley   +1 more source
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History of clinical trials

Seminars in Oncology Nursing, 1991
Advances in medical treatments have occurred because of the application of new knowledge gained from clinical experiments conducted over the last 250 years. New sources of compounds with anti-tumor activity in human cancer are constantly under investigation.
J, Jenkins, S, Hubbard
openaire   +2 more sources

History of Clinical Pharmacy and Clinical Pharmacology

The Journal of Clinical Pharmacology, 1981
Abstract: The purpose of the Symposium on Clinical Pharmacy and Clinical Pharmacology is to describe the present and future functional roles of clinical pharmacists and clinical pharmacologists in drug research, professional education, and patient care. Clinical pharmacy is a relatively new professional discipline, being only about 15 years old.
openaire   +2 more sources

Clinical Neuropsychology: A Brief History

Disease-a-Month, 2007
Clinical Neuropsychology is the discipline that investigates the interrelations of the human brain with thinking and behavior on the basis of the variations in brain function produced by injury or disease. That such injury caused mental impairment must have been apparent even to primitive man who resorted to trephining in an attempt to alleviate its ...
A L, Benton, A B, Sivan
openaire   +2 more sources

Hemodiafiltration History, Technology, and Clinical Results

Advances in Chronic Kidney Disease, 2007
Hemodiafiltration (HDF) is an extracorporeal renal-replacement technique using a highly permeable membrane, in which diffusion and convection are conveniently combined to enhance solute removal in a wide spectrum of molecular weights. In this modality, ultrafiltration exceeds the desired fluid loss in the patient, and replacement fluid must be ...
Ronco C, Cruz D
openaire   +3 more sources

Clinical History and Clinical Correlation

2015
A surgical pathologist’s first responsibility is towards the patient from whom the specimen has been taken. The importance of clinical information and clinical correlation is recognized by pathologists and regulatory agencies. Such information is vital in leading to a diagnosis that is accurate and appropriately specific.
openaire   +1 more source

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