Results 331 to 340 of about 16,868,271 (383)

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

open access: yesFEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani   +7 more
wiley   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

open access: yesFEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima   +4 more
wiley   +1 more source
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Impact of Clinical History on Maximum PI-RADS Version 2 Score: A Six-Reader 120-Case Sham History Retrospective Evaluation.

Radiology, 2018
Purpose To assess the impact of clinical history on the maximum Prostate Imaging Recording and Data System (PI-RADS) version 2 (v2) score assigned to multiparametric magnetic resonance (MR) imaging of the prostate.
Prasad R. Shankar   +8 more
semanticscholar   +1 more source

History of clinical trials

Seminars in Oncology Nursing, 1991
Advances in medical treatments have occurred because of the application of new knowledge gained from clinical experiments conducted over the last 250 years. New sources of compounds with anti-tumor activity in human cancer are constantly under investigation.
J, Jenkins, S, Hubbard
openaire   +2 more sources

History of Clinical Pharmacy and Clinical Pharmacology

The Journal of Clinical Pharmacology, 1981
Abstract: The purpose of the Symposium on Clinical Pharmacy and Clinical Pharmacology is to describe the present and future functional roles of clinical pharmacists and clinical pharmacologists in drug research, professional education, and patient care. Clinical pharmacy is a relatively new professional discipline, being only about 15 years old.
openaire   +2 more sources

Clinical Neuropsychology: A Brief History

Disease-a-Month, 2007
Clinical Neuropsychology is the discipline that investigates the interrelations of the human brain with thinking and behavior on the basis of the variations in brain function produced by injury or disease. That such injury caused mental impairment must have been apparent even to primitive man who resorted to trephining in an attempt to alleviate its ...
A L, Benton, A B, Sivan
openaire   +2 more sources

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