Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Clinical indications for dialysis: a study of patient demographics at Hargeisa Group Hospital, Somaliland. [PDF]
BMC NephrolIbrahim N, Mohamoud AA, Ali AO.
europepmc +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Zygomatic Implants for Rehabilitation of the Atrophic Maxilla: Clinical Indications, Outcomes, Complications, and Evidence Gaps-A Comprehensive Review. [PDF]
Medicina (Kaunas)Acerra A +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Assessing the clinical utility of ultrasound in general practitioner practices: A systematic review of beneficial and non-beneficial indications : Search strategies [PDF]
Research question The use of ultrasound diagnostic imaging is increasing. Despite the importance of ultrasound, studies indicate that a significant proportion of ultrasound investigations may not significantly impact patient care, meaning the imaging ...
Aubert, Carole E +3 more
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Ketamine Dosing Across Clinical Indications: A Narrative Review Organized by Proposed NMDA-Related Mechanisms. [PDF]
J Clin PharmacolGlue P, Beaglehole B.
europepmc +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Role of SIRT in Patients With Hepatocellular Carcinoma: Current Clinical Indications and Future Perspectives. [PDF]
In VivoFaggian G +6 more
europepmc +1 more source