Results 51 to 60 of about 6,057,330 (258)

Systematic drug repositioning based on clinical side-effects. [PDF]

PLoS ONE, 2011
Drug repositioning helps fully explore indications for marketed drugs and clinical candidates. Here we show that the clinical side-effects (SEs) provide a human phenotypic profile for the drug, and this profile can suggest additional disease indications.
Lun Yang, Pankaj Agarwal
doaj   +1 more source

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

Tonsillectomy among children with low baseline acute throat infection consultation rates in UK general practices: a cohort study. [PDF]

, 2014
OBJECTIVE: To investigate the effectiveness of tonsillectomy in reducing acute throat infection (ATI) consultation rates over 6 years' follow-up among children with low baseline ATI consultation rates. DESIGN: Retrospective cohort study.
Saxena, S, Bottle, Alex, Watt, H, Curcin, V, Watt, Hilary, Sharland, Mike, Koshy, E, Bottle, A, Sharland, M, Saxena, Sonia, Koshy, Elizabeth, Curcin, Vasa; id_orcid   +11 more
core   +1 more source

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

Expansion of a recent class of broad-spectrum antifungal agents: the echinocandins

Microbiologia Medica, 2009
The echinocandins show comparable efficacy in the treatment of candidemia and invasive candidiasis. Caspofungin and micafungin appear to be similarly efficacious in salvage therapy in aspergillosis; anidulafungin has excellent in vitro activity against ...
Roberto Manfredi
doaj   +1 more source

The Impact of the COVID‐19 Pandemic on Childhood Cancer Survival: A Population‐Based Assessment of Survival Patterns Between 2015 and 2023 in Germany

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Numerous international studies have reported declines in new cancer diagnoses, delayed diagnoses and disruptions in cancer treatment following the implementation of COVID‐19 pandemic public health measures, raising concerns that these effects may ultimately contribute to increased cancer mortality.
Friederike Erdmann, Maike Wellbrock, Javier Louro, Arndt Borkhardt, Martin Schrappe, Claudia Trübenbach, Desiree Grabow, Cécile M. Ronckers, Joachim Schüz   +8 more
wiley   +1 more source

Referral Patterns and Diagnostic Timeliness in Pediatric Cancer: A Hospital‐Based Study in Indonesia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Timely diagnosis and treatment are critical for improving survival among children with cancer. In low‐ and middle‐income countries (LMICs), delays are common and may be influenced by fragmented referral pathways and diagnostic limitations.
Nur Melani Sari, Regina Hadi Putri, Fatimah Assyifa, Judith Spijkerman, Gertjan Johannes Kaspers, Susi Susanah   +5 more
wiley   +1 more source

Clinical Pharmacokinetics of Systemically Administered Antileishmanial Drugs [PDF]

, 2017
This review describes the pharmacokinetic properties of the systemically administered antileishmanial drugs pentavalent antimony, paromomycin, pentamidine, miltefosine and amphotericin B (AMB), including their absorption, distribution, metabolism and ...
Schellens, Jan H M, Dorlo, Thomas P. C.,, Kip, Anke E., Thomas P. C. Dorlo, Kip, Anke E, Schellens, Jan H. M., Beijnen, Jos H., Beijnen, Jos H.,, Schellens, Jan H. M.,, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Dorlo, Thomas P. C., Dorlo, Thomas P C, Anke E. Kip, Kip, Anke E.,, Jos H. Beijnen, Beijnen, Jos H, Jan H. M. Schellens   +17 more
core   +1 more source

Analysis on Characteristics and Regularities of Efficacies of Acupoint Injection by Using Data Mining Technique

针刺研究, 2012
Objective To analyze the potential learning and regularity characters of clinical application of acupoint in-jection in modern literature of Chinese medicine by using data mining technique,so as to provide a reference for clinical application of this ...
XU Xiao-kang, JIA Chun-sheng, WANG Jian-ling1, SHI Jing1, QIN Liang2, ZHANG Xin, ZHANG Xuan-ping   +6 more
doaj   +2 more sources

SCMR Position Paper (2020) on clinical indications for cardiovascular magnetic resonance

Journal of Cardiovascular Magnetic Resonance, 2020
The Society for Cardiovascular Magnetic Resonance (SCMR) last published its comprehensive expert panel report of clinical indications for CMR in 2004.
Tim Leiner, Jan Bogaert, Matthias G. Friedrich, Raad Mohiaddin, Vivek Muthurangu, Saul Myerson, Andrew J. Powell, Subha V. Raman, Dudley J. Pennell   +8 more
doaj   +1 more source