Results 31 to 40 of about 194,487 (259)

Clinical Research Informatics: Contributions from 2022

Yearbook of Medical Informatics, 2023
Objectives: To summarize key contributions to current research in the field of Clinical Research Informatics (CRI) and to select best papers published in 2022. Method: A bibliographic search using a combination of Medical Subject Headings (MeSH) descriptors and free-text terms on CRI was performed using PubMed, followed by a ...
Tannier, Xavier, Kalra, Dipak, Section Editors for the IMIA Yearbook Section on Clinical Research Informatics, [missing]   +2 more
openaire   +5 more sources

“Après Mois, Le Déluge”: Preparing for the Coming Data Flood in the MRI-Guided Radiotherapy Era

Frontiers in Oncology, 2019
Magnetic resonance imaging provides a sea of quantitative and semi-quantitative data. While radiation oncologists already navigate a pool of clinical (semantic) and imaging data, the tide will swell with the advent of hybrid MRI/linear accelerator ...
Kendall J. Kiser, Kendall J. Kiser, Kendall J. Kiser, Benjamin D. Smith, Jihong Wang, Clifton D. Fuller   +5 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

A core curriculum for clinical fellowship training in pathology informatics

Journal of Pathology Informatics, 2012
Background: In 2007, our healthcare system established a clinical fellowship program in Pathology Informatics. In 2010 a core didactic course was implemented to supplement the fellowship research and operational rotations.
David S McClintock, Bruce P Levy, William J Lane, Roy E Lee, Jason M Baron, Veronica E Klepeis, Maristela L Onozato, JiYeon Kim, Anand S Dighe, Bruce A Beckwith, Frank Kuo, Stephen Black-Schaffer, John R Gilbertson   +12 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Natural language processing and machine learning to enable automatic extraction and classification of patients’ smoking status from electronic medical records

Upsala Journal of Medical Sciences, 2020
Background The electronic medical record (EMR) offers unique possibilities for clinical research, but some important patient attributes are not readily available due to its unstructured properties.
Andrea Caccamisi, Leif Jørgensen, Hercules Dalianis, Mats Rosenlund   +3 more
doaj   +1 more source

Clinical Research Informatics: Contributions from 2018 [PDF]

Yearbook of Medical Informatics, 2019
Objectives: To summarize key contributions to current research in the field of Clinical Research Informatics (CRI) and to select best papers published in 2018. Method: A bibliographic search using a combination of MeSH descriptors and free-text terms on CRI was performed using PubMed, followed by a double-blind review in order ...
Daniel, Christel, Kalra, Dipak, Section Editors for the IMIA Yearbook Section on Clinical Research Informatics, [missing]   +2 more
openaire   +4 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Perceptions of nursing informatics on quality of nursing practice and competency among nurses in Jordan

Frontiers in Digital Health
BackgroundThe application of nursing informatics and its specific components, such as the EHR/EMR comes with an array of positive implications. However, these benefits are poorly explored in Jordan as a country where digitized nursing information still ...
Rami Alnajjar, Amr Zyoud, Hanan Al-Shamaly, Abdelrhman Tamimi, Moath AbedRabbu   +4 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source