Results 31 to 40 of about 5,849,043 (235)

“Après Mois, Le Déluge”: Preparing for the Coming Data Flood in the MRI-Guided Radiotherapy Era

Frontiers in Oncology, 2019
Magnetic resonance imaging provides a sea of quantitative and semi-quantitative data. While radiation oncologists already navigate a pool of clinical (semantic) and imaging data, the tide will swell with the advent of hybrid MRI/linear accelerator ...
Kendall J. Kiser, Kendall J. Kiser, Kendall J. Kiser, Benjamin D. Smith, Jihong Wang, Clifton D. Fuller   +5 more
doaj   +1 more source

Natural language processing and machine learning to enable automatic extraction and classification of patients’ smoking status from electronic medical records

Upsala Journal of Medical Sciences, 2020
Background The electronic medical record (EMR) offers unique possibilities for clinical research, but some important patient attributes are not readily available due to its unstructured properties.
Andrea Caccamisi, Leif Jørgensen, Hercules Dalianis, Mats Rosenlund   +3 more
doaj   +1 more source

Application of informatics in cancer research and clinical practice: Opportunities and challenges

Cancer Innovation, 2022
Cancer informatics has significantly progressed in the big data era. We summarize the application of informatics approaches to the cancer domain from both the informatics perspective (e.g., data management and data science) and the clinical perspective ...
Na Hong, Gang Sun, Xiuran Zuo, Meng Chen, Li Liu, Jiani Wang, Xiaobin Feng, Wenzhao Shi, Mengchun Gong, Pengcheng Ma   +9 more
doaj   +1 more source

A core curriculum for clinical fellowship training in pathology informatics

Journal of Pathology Informatics, 2012
Background: In 2007, our healthcare system established a clinical fellowship program in Pathology Informatics. In 2010 a core didactic course was implemented to supplement the fellowship research and operational rotations.
David S McClintock, Bruce P Levy, William J Lane, Roy E Lee, Jason M Baron, Veronica E Klepeis, Maristela L Onozato, JiYeon Kim, Anand S Dighe, Bruce A Beckwith, Frank Kuo, Stephen Black-Schaffer, John R Gilbertson   +12 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Perceptions of nursing informatics on quality of nursing practice and competency among nurses in Jordan

Frontiers in Digital Health
BackgroundThe application of nursing informatics and its specific components, such as the EHR/EMR comes with an array of positive implications. However, these benefits are poorly explored in Jordan as a country where digitized nursing information still ...
Rami Alnajjar, Amr Zyoud, Hanan Al-Shamaly, Abdelrhman Tamimi, Moath AbedRabbu   +4 more
doaj   +1 more source

Structure and Funding of Clinical Informatics Fellowships: A National Survey of Program Directors. [PDF]

Appl Clin Inform
BACKGROUND: In 2011, the American Board of Medical Specialties established clinical informatics (CI) as a subspecialty in medicine, jointly administered by the American Board of Pathology and the American Board of Preventive Medicine.
Patel TN, Chaise AJ, Hanna JJ, Patel KP, Kochendorfer KM, Medford RJ, Mize DE, Melnick ER, Hron JD, Youens K, Pandita D, Leu MG, Ator GA, Yu F, Genes N, Baker CK, Bell DS, Pevnick JM, Conrad SA, Chandawarkar AR, Rogers KM, Kaelber DC, Singh IR, Levy BP, Finnell JT, Kannry J, Pageler NM, Mohan V, Lehmann CU.   +28 more
europepmc   +2 more sources

Understanding Further the Phenotypic Spectrum of Central Nervous System Inflammatory Demyelinating Disorders Using Unsupervised Clustering

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Central nervous system (CNS) inflammatory demyelinating syndromes, including multiple sclerosis (MS), aquaporin‐4 antibody–positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD), and myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD), occasionally overlap.
Bade Gulec, Elif Everest, Melih Tutuncu, Ugur Bilge, Sabahattin Saip, Ugur Uygunoglu, Aksel Siva   +6 more
wiley   +1 more source