Results 101 to 110 of about 28,764,040 (274)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Strategic management plan for geographic information systems technology Geographic information systems technology

, 1990
"September 1990."Section 1: Executive Summary -- Section 2: Organization of the Plan -- Section 3: Strategic Planning Policy -- Section 4: Goals of the GIS Technology Management Plan -- Section 5: Background -- Section 6: The Potential of GIS Technology ...
Kansas Geographic Information Systems Policy Board
core  

Estimation of minimal data sets sizes for machine learning predictions in digital mental health interventions

npj Digital Medicine
Artificial intelligence promises to revolutionize mental health care, but small dataset sizes and lack of robust methods raise concerns about result generalizability.
Kirsten Zantvoort, Barbara Nacke, Dennis Görlich, Silvan Hornstein, Corinna Jacobi, Burkhardt Funk   +5 more
doaj   +1 more source

Mobile Crowdsensing in Ecological Momentary Assessment mHealth Studies: A Systematic Review and Analysis

Sensors
As mobile devices have become a central part of our daily lives, they are also becoming increasingly important in research. In the medical context, for example, smartphones are used to collect ecologically valid and longitudinal data using Ecological ...
Robin Kraft, Manfred Reichert, Rüdiger Pryss   +2 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

A User Study on Modeling IoT-Aware Processes with BPMN 2.0

Information
Integrating the Internet of Things (IoT) into business process management (BPM) aims to increase the automation level, efficiency, transparency, and comprehensibility of the business processes taking place in the physical world.
Yusuf Kirikkayis, Michael Winter, Manfred Reichert   +2 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Dataset size versus homogeneity: A machine learning study on pooling intervention data in e-mental health dropout predictions

Digital Health
Objective This study proposes a way of increasing dataset sizes for machine learning tasks in Internet-based Cognitive Behavioral Therapy through pooling interventions.
Kirsten Zantvoort, Nils Hentati Isacsson, Burkhardt Funk, Viktor Kaldo   +3 more
doaj   +1 more source

Trends in Clinical Information Systems Research in 2019. [PDF]

Yearb Med Inform, 2020
Hackl WO, Hoerbst A, Section Editors for the IMIA Yearbook Section on Clinical Information Systems.   +2 more
europepmc   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source