Results 101 to 110 of about 29,665,310 (345)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Using machine learning methods to investigate the impact of comorbidities and clinical indicators on the mortality rate of COVID-19

Frontiers in Medical Technology
BackgroundThis study aims to develop a machine learning model to predict the 30-day mortality risk of hospitalized COVID-19 patients while leveraging federated learning to enhance data privacy and expand the model's applicability.
Yueh-Chen Hsieh, Sin Chen, Shu-Yu Tsao, Jiun-Ruey Hu, Wan-Ting Hsu, Wan-Ting Hsu, Chien-Chang Lee, Chien-Chang Lee, Chien-Chang Lee   +8 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Portuguese observational cross-sectional clinical imaging study protocol to investigate central dopaminergic mechanisms of successful weight loss through bariatric surgery

BMJ Open
Introduction Bariatric surgery (BS) is the treatment of choice for refractory obesity. Although weight loss (WL) reduces the prevalence of obesity-related comorbidities, not all patients maintain it.
Miguel Castelo-Branco, Marta Lapo Pais, Joana Crisóstomo, Antero Abrunhosa   +3 more
doaj   +1 more source

Defining stopping criteria for ending randomized clinical trials that investigate the interruption of transmission of soil-transmitted helminths employing mass drug administration.

PLoS Neglected Tropical Diseases, 2018
The current World Health Organization strategy to address soil-transmitted helminth (STH) infections in children is based on morbidity control through routine deworming of school and pre-school aged children. However, given that transmission continues to
Marleen Werkman, Jaspreet Toor, Carolin Vegvari, James E Wright, James E Truscott, Kristjana H Ásbjörnsdóttir, Arianna Rubin Means, Judd L Walson, Roy M Anderson   +8 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Clinical Investigations [PDF]

Academic Emergency Medicine, 2002
Daniel J. Edwards, Peter B. Richman, Keith Bradley, Barnet Eskin, Mark Mandell   +4 more
openaire   +3 more sources

Process mining to investigate the relationship between clinical antecedents and injury risk, severity and return to play in professional sports

BMJ Open Sport & Exercise Medicine
Objective This paper presents an exploratory case study focusing on the applicability and value of process mining in a professional sports healthcare setting. We explore whether process mining can be retrospectively applied to readily available data at a
Evert Verhagen, Ramon Pi-Rusiñol, Gil Rodas Font, Miriam Blanc   +3 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

A qualitative interview study to investigate opportunities for improvement in routine asthma care using a clinical decision support system

Scientific Reports
More than 8 million people in the UK have been diagnosed with asthma, a chronic respiratory condition which leads to the death of more than 25 people per week.
Holly Tibble, Jaime Garcia Iglesias, Alexandria Chung   +2 more
doaj   +1 more source