Results 131 to 140 of about 29,665,310 (345)

Protocol for a prospective open-label clinical trial to investigate the utility of concurrent TBS/fNIRS for antidepressant treatment optimisation

BMJ Open, 2022
Kenneth N K Fong, Rebecca L D Kan, Arthur D P Mak, Sherry K W Chan, Bella B B Zhang, Georg S Kranz   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The use of meta-analysis in economic evaluation [PDF]

Meta-analysis provides a family of statistical techniques for combining the results of similar studies. This paper examines the meta-analysis of clinical data in economic studies, and points to the issues and considerations that must be addressed when ...
Francis Pang, Fujian Song, Mike Drummond
core  

EMT, CSCs, and drug resistance: the mechanistic link and clinical implications

Nature Reviews Clinical Oncology, 2017
T. Shibue, R. Weinberg
semanticscholar   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy.

New England Journal of Medicine, 2015
C. Templin, J. Ghadri, J. Diekmann, L. C. Napp, D. Bataiosu, M. Jaguszewski, V. L. Cammann, A. Sarcon, V. Geyer, C. A. Neumann, B. Seifert, J. Hellermann, Moritz Schwyzer, Katharina Eisenhardt, J. Jenewein, J. Franke, H. Katus, C. Burgdorf, H. Schunkert, C. Moeller, H. Thiele, J. Bauersachs, C. Tschöpe, H. Schultheiss, C. Laney, Lawrence Rajan, G. Michels, R. Pfister, C. Ukena, M. Böhm, R. Erbel, A. Cuneo, K. Kuck, C. Jacobshagen, G. Hasenfuss, M. Karakas, W. Koenig, W. Rottbauer, S. Said, R. Braun-Dullaeus, F. Cuculi, A. Banning, T. Fischer, T. Vasankari, K. Airaksinen, M. Fijałkowski, A. Rynkiewicz, M. Pawlak, G. Opolski, R. Dworakowski, P. MacCarthy, C. Kaiser, S. Osswald, L. Galiuto, F. Crea, W. Dichtl, W. Franz, K. Empen, S. Felix, C. Delmas, O. Lairez, P. Erne, Jeroen J. Bax, I. Ford, F. Ruschitzka, A. Prasad, T. Lüscher   +66 more
semanticscholar   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Knockdown and Overexpression Experiments to Investigate the Inhibitory Mechanism of Fuzheng Xiaozheng Prescription, an Effective Chinese Herbal Formula for the Clinical Treatment of Hepatocellular Carcinoma

Pharmaceuticals
Fuzheng Xiaozheng prescription (FZXZP) is an effective formula for the treatment of different kinds of chronic liver diseases. However, its potential molecular mechanisms in treating hepatocellular carcinoma (HCC) have not been investigated thoroughly ...
Xia Li, Xiaofeng Chen, Han Yu, Renwei Huang, Peijie Wu, Yanju Gong, Xiping Chen, Chao Liu   +7 more
doaj   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Clinical validation of an RSV neutralization assay and analysis of cross-sectional sera associated with 2021–2023 RSV outbreaks to investigate the immunity debt hypothesis

Microbiology Spectrum
Respiratory syncytial virus (RSV) is a leading cause of acute respiratory infections and hospitalization in infants and the elderly. Newly approved vaccines and the prophylactic antibody nirsevimab have heightened interest in RSV immunologic surveillance,
Eli A. Piliper, Jonathan C. Reed, Alexander L. Greninger   +2 more
doaj   +1 more source