Results 211 to 220 of about 2,120,941 (241)
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Microarrays and Clinical Investigations
New England Journal of Medicine, 2004Two articles in this issue of the Journal tell a similar story: primary acute myeloid leukemia (AML) may be divided into subclasses according to gene-expression profiles.
Edison T, Liu, Krishna R, Karuturi
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Blind as a Clinical Investigator
New England Journal of Medicine, 1973"O heavens, this is my true-begotten father! who, being more than sand-blind, high-gravel blind, knows me not." The Merchant of Venice II, ii, 36 One of the silliest linguistic conventions to which medical academicians are addicted is the use of blindness to convey the sense of bias control.
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The Clinical Investigation of Dementia
The Canadian Journal of Psychiatry, 1983The clinical investigation of 63 patients with a hospital discharge diagnosis of dementia was reviewed. The review focused on the completeness of ancillary investigations to detect treatable causes of dementia, and on the follow-up examination to confirm the diagnosis.
B A, Martin +2 more
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Serendipity in Clinical Investigation
JAMA: The Journal of the American Medical Association, 1969Serendipity is one of my favorite words. Not only is it euphonious but its meaning carries overtones and innuendos of precise yet ephemeral nature, as so many French words do, and so few do in our own language. The word was invented by Horace Walpole; but, with its wide popularity, the original meaning has often been corrupted to signify everything ...
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Investigative Clinical Pharmacology
Clinical Pharmacology & Therapeutics, 2011Clinical pharmacology is an essential discipline in the development of new medicines, but the closely specified requirements of pharmaceutical industry protocols and regulatory reviewers have limited the opportunities for curiosity-driven research. Realization is growing that there is so much that is not known about the mechanisms underlying human ...
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Introduction to Clinical Investigation
JAMA, 1964THE INITIAL clinical trial is a crucial matter in the development of a new drug. The risk inherent in its first use in man, and the need to obtain a true evaluation of its action before large sums of money are invested in materials, make it imperative that the initial trial be a well-controlled study.
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The clinical investigator as target
Controlled Clinical Trials, 1996Misconduct in scientific research has been given increasing attention during the past two decades. Whether charges of misconduct, misconduct itself, or public concern about it have been on the rise is unclear, but actions taken by professional and medical organizations, universities, and government evidence a reaction to the increased attention.
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Clinical Investigation and JAMA
JAMA: The Journal of the American Medical Association, 1987Modern medicine is an increasingly complex and troubled profession, but most will agree that science is at its heart. People know this and demand technical and scientific excellence as well as caring from their physicians. Consumers' wishes aside, the constant evaluation and reevaluation of the knowledge base in medicine—pathogenesis, diagnosis, and ...
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CHANGING TRENDS IN CLINICAL INVESTIGATION
Journal of the American Medical Association, 1959Changing trends in American medicine, medical education, and research have for many years been favorite subjects for messages from chairmen. Nevertheless, since this represents the Centennial Meeting of the Section on Experimental Medicine and Therapeutics, it seems timely to discuss briefly a few of the problems related to the dynamic developments in ...
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2010
Abstract Disease markers are pathological or physiological characteristics of an individual that assist in determining the diagnosis, the current activity of disease, or the expected prognosis of the condition in that individual. Some markers relate to just one of these elements; others may relate to two, or occasionally all three ...
Michael Doherty, Peter C. Lanyon
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Abstract Disease markers are pathological or physiological characteristics of an individual that assist in determining the diagnosis, the current activity of disease, or the expected prognosis of the condition in that individual. Some markers relate to just one of these elements; others may relate to two, or occasionally all three ...
Michael Doherty, Peter C. Lanyon
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