Results 101 to 110 of about 3,073,351 (268)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Impacto de la automatización de los ensayos analíticos en los servicios oncológicos del Laboratorio Clínico Impact of the automation of the analytic assays in the oncological services of the Clinical Laboratory

Medisan, 2012
Se diseñó una investigación longitudinal y prospectiva para evaluar la efectividad de la tecnología Elimat en el Laboratorio Clínico del Hospital Oncológico Docente “Conrado Benítez” de Santiago de Cuba, durante el bienio 2010-2011, al ...
María Cristina Céspedes Quevedo, María Eulalia ópez Mediacejas, Liurka Cuesta Alexis, Zulema Cobas Ramos, Yordanka Pérez Taquechel   +4 more
doaj  

Systematic reviews of clinical laboratory studies: Pilot risk of bias tool developed by consensus

Cochrane Evidence Synthesis and Methods
Introduction Some research studies aim to elucidate pathophysiology by examining blood or tissue markers in relation to clinical findings. In COVID‐19, this has led specialists to promote treatment options based on single studies without systematic ...
Tilly Fox, Beverley J. Hunt, Robert A. S. Ariens, Greg J. Towers, Robert Lever, Paul Garner, Rebecca Kuehn   +6 more
doaj   +1 more source

SAFETY IN CLINICAL LABORATORIES [PDF]

The Lancet, 1979
H M, Dick, H B, Goodall, P D, Griffiths, N R, Grist, F D, Lee, J D, Sleigh   +5 more
openaire   +3 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Método clínico vs laboratorio clínico Clinical method vs clinical laboratory

Revista Médica Electrónica, 2011
El desarrollo del laboratorio clínico a finales del siglo XX, impulsado por los grandes avances tecnológicos, se ha sumado al progreso social. En la atención al paciente, este desarrollo ha permitido contar con un sistema más integral para el cuidado de ...
Leydiana Trimiño Galindo, Mario Jorge Padrón Ramos, Layanis Guardarrama Linares, Dalia García Cuervo, Juana María Rubiera García   +4 more
doaj  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Clinical laboratory optimization

Optimisation des laboratoires d'analyses médicales Cette thèse porte sur l'optimisation de la conception et des décisions opérationnelles des laboratoires d'analyses médicales. Dans cette thèse, un outil d'aide à la décision comprenant des modèles mathématiques, un algorithme heuristique et un modèle de simulation personnalisé est ...
openaire   +2 more sources

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Editorial: Impact of COVID-19 on the clinical microbiology laboratory: Preparing for the next pandemic

Frontiers in Cellular and Infection Microbiology, 2022
Sherry Dunbar, Esther Babady, Sanchita Das, Catherine Moore   +3 more
doaj   +1 more source